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Clinically relevant increases in the international normalized ratio and model of end-stage liver disease score by therapeutic doses of direct oral anticoagulants in patients with cirrhosis

التفاصيل البيبلوغرافية
العنوان: Clinically relevant increases in the international normalized ratio and model of end-stage liver disease score by therapeutic doses of direct oral anticoagulants in patients with cirrhosis
المؤلفون: Ton Lisman, William Bernal, Jelle Adelmeijer, Pieter-Willem Kamphuisen, Sarah Bos, Robert J. Porte
المساهمون: Groningen Institute for Organ Transplantation (GIOT), Vascular Medicine, ACS - Pulmonary hypertension & thrombosis, ACS - Amsterdam Cardiovascular Sciences
المصدر: Research and practice in thrombosis and haemostasis, 7(1):100052. Wiley
Research and practice in thrombosis and haemostasis, 7(1):100052. Wiley-Blackwell Publishing Ltd
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
مصطلحات موضوعية: anticoagulants, liver transplantation, end-stage liver disease, cirrhosis, international normalized ratio, Hematology
الوصف: Background: Patients with cirrhosis are increasingly using direct oral anticoagulants (DOACs) in therapeutic doses for the treatment of portal vein thrombosis or for concomitant atrial fibrillation. DOACs may affect routine diagnostic tests of coagulation including the international normalized ratio (INR). The INR is a part of the model of end-stage liver disease (MELD) score, a validated score that predicts the mortality risk in patients with cirrhosis and is used to prioritize patients for liver transplantation. DOAC–induced increases in the INR may thus lead to artificial inflation of the MELD score. Objective: We studied the effect of DOACs on INR prolongation in patients with cirrhosis. Methods: We spiked plasma from 20 healthy individuals and 20 patients at the start of liver transplantation with DOACs in concentrations representing peak therapeutic levels. In addition, we studied INR increases in healthy controls and patients with mild cirrhosis who received the DOAC edoxaban for 1 week for study purposes. Results: In controls and patients, the INR increased by an ex vivo addition of a DOAC, and the INR increase in patients was proportional to the baseline INR values. The increase in INR translated to a median increase of between 3 and 10 MELD points, depending on the DOAC used. In controls and patients alike, the INR increased on the ingestion of edoxaban, which translated to an increase in 5 MELD points. Conclusions: Taken together, DOACs result in an INR increase that translates to clinically meaningful increases in MELD points in patients with cirrhosis, and precautions to avoid artificial inflation of the MELD score in these patients are warranted.
وصف الملف: application/pdf
اللغة: English
تدمد: 2475-0379
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e5a2c48fd53df788af667120d86510
https://research.rug.nl/en/publications/ff3161db-033f-4246-a197-d76bcaf79d3e
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....75e5a2c48fd53df788af667120d86510
قاعدة البيانات: OpenAIRE
الوصف
تدمد:24750379