Predictive and prognostic clinical and pathological factors of nivolumab efficacy in non-small-cell lung cancer patients
| العنوان: | Predictive and prognostic clinical and pathological factors of nivolumab efficacy in non-small-cell lung cancer patients |
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| المؤلفون: | Miguel Martín, C. Salvador-Coloma, Alejandro Ferrando Sánchez, José García-Sánchez, A. Blasco-Cordellat, F. Aparisi, S. Marin-Liebana, S. Blasco-Molla, J. Perez-Altozano, P. Martin-Martorell, Javier Garde-Noguera, D. Marquez-Medina, X. Mielgo-Rubio, M. A. de la Casa de Julian, R. Gironés, A. Insa-Molla, M. C. Bas Cerda, S. Macia-Escalante, O. Juan-Vidal |
| المصدر: | CLINICAL & TRANSLATIONAL ONCOLOGY r-FISABIO. Repositorio Institucional de Producción Científica instname r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe r-FHPC. Repositorio Institucional de Producción Científica de la Fundación del Hospital Provincial de Castellón r-FIHGUV. Repositorio Institucional de Producción Científica de la Fundación de Investigación del Hospital General de Valencia |
| بيانات النشر: | SPRINGER-VERLAG ITALIA SRL, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Lung Neoplasms, GIDO, Antineoplastic Agents, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Carcinoma, Non-Small-Cell Lung, medicine, Humans, Progression-free survival, Stage (cooking), Neoplasm Metastasis, Lung cancer, Survival rate, Aged, Retrospective Studies, Performance status, business.industry, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Prognosis, Survival Rate, 030104 developmental biology, Nivolumab, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Female, Immunotherapy, Neoplasm Recurrence, Local, business, Non-small-cell lung cancer, Brain metastasis, Follow-Up Studies |
| الوصف: | Immunotherapy increases overall response rate (ORR) and overall survival (OS) in patients with non-small-cell lung cancer (NSCLC). Prognostic and predictive factors are a high need. Retrospective review of NSCLC patients treated with nivolumab was performed. Analyzed variables included age, sex, stage, performance status (PS), location of metastases, presence of tumour-related symptoms and comorbidities, number of metastasis locations, previous chemotherapy, anti-angiogenic and radiotherapy treatments, and analytical data from the standard blood count and biochemistry. A total of 175 patients were included. Median age was 61.5 years, 73.1% were men, 77.7% were ECOG-PS 0-1, and 86.7% were included with stage IV disease. Histology was non-squamous in 77.1%. Sixty-five received nivolumab in second line (37.1%). Thirty-eight patients had brain metastasis (22%), and 39 (22.3%) liver metastasis and 126 (72%) had more than one metastatic location. The ORR was 15.7% with median Progression free survival (PFS) 2.8 months and median OS 5.81 months. Stage III vs IV and time since the beginning of the previous line of treatment 6 vs < 6 months were associated with better response. PS 2, time since the previous line of treatment < 6 vs 6 months, and more than one metastatic location were independently associated with shorter OS in multivariable analysis (7.8 vs 2.7 months, 11.2 vs 4.6 months, and 9.4 vs 5.1 month). Finally, time since the previous treatment < 6 vs 6 months and more than one metastatic location were independently associated with shorter PFS in multivariable analysis (4.3 vs 2.3 months and 4.7 vs 2.3 months). Poor PS, short period of time since the previous treatment, and more than one metastatic location were associated with poorer prognostic. |
| تدمد: | 1699-048X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76439cc85ca95322d63cd77b0ad45c4c https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2587 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....76439cc85ca95322d63cd77b0ad45c4c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 1699048X |
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