Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19
| العنوان: | Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19 |
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| المؤلفون: | Kuznik Bi, V. Kh. Khavinson, A. V. Trofimov, E. Magen, V. A. Volchkov, S A Rukavishnikova, T A Akhmedov, O. N. Titova, V V Potemkin, S. V. Trofimova |
| المصدر: | Stem Cell Reviews and Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Thymalin, medicine.medical_treatment, T cell, Peptide, Thymus Gland, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, chemistry.chemical_classification, Hemostasis, SARS-CoV-2, Activator (genetics), Hematopoietic stem cell differentiation, Immunity, COVID-19, Cell Differentiation, Biological activity, Hematopoietic Stem Cells, Hematopoiesis, COVID-19 Drug Treatment, Thymus Hormones, Haematopoiesis, 030104 developmental biology, Cytokine, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Cancer research, Cytokines, Standard therapy, Stem cell, Peptides |
| الوصف: | Graphical Abstract The paper presents the results of a standard and complex treatment method using the peptide drug thymus thymalin in patients with COVID-19. One of the mechanisms of the immunomodulatory effect of thymalin is considered to be the ability of this peptide drug to influence the differentiation of human hematopoietic stem cells (HSCs). It was found that, as a result of standard treatment, patients in the control group showed a decrease in the concentration of the pro-inflammatory cytokine IL-6, C-reactive protein, D-dimer. The addition of thymalin to standard therapy accelerated the decline in both these indicators and the indicators of the T cell system. This has helped reduce the risk of blood clots in COVID-19 patients. The revealed properties of the thymus peptide preparation are the rationale for its inclusion in the complex treatment of coronavirus infection. Peptideswith potential biological activity against SARS-CoV-2 virus [29]. Note: Nitrogen atoms are shown in blue, oxygen atoms - in red, carbon atoms – in gray, hydrogen atoms – in white, and phosphorus atoms – in yellow |
| تدمد: | 2629-3277 2629-3269 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7678b5b32e1dae2d9c171958304a332d https://doi.org/10.1007/s12015-020-10087-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7678b5b32e1dae2d9c171958304a332d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 26293277 26293269 |
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