Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis
| العنوان: | Misshapen Disruption Cooperates with RasV12 to Drive Tumorigenesis |
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| المؤلفون: | Sihua Zhao, Du Kong, Xiaoqin Li, Wenyan Xu, Jinan Fang, Xianjue Ma, Jin-Yu Lu, Xing Wang |
| المصدر: | Cells Cells, Vol 10, Iss 894, p 894 (2021) Volume 10 Issue 4 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | animal structures, Carcinogenesis, Protocadherin, Protein Serine-Threonine Kinases, Biology, medicine.disease_cause, Article, Cell Line, law.invention, Hippo, law, medicine, Animals, Drosophila Proteins, Neoplasm Invasiveness, Msn, lcsh:QH301-705.5, Feedback, Physiological, Hippo signaling pathway, Ras, fungi, JNK Mitogen-Activated Protein Kinases, General Medicine, Cell biology, body regions, tumorigenesis, Imaginal disc, Crosstalk (biology), Drosophila melanogaster, Drosophila, Ft, lcsh:Biology (General), Hippo signaling, Mutation, ras Proteins, Suppressor, sense organs, Signal Transduction, Genetic screen |
| الوصف: | Although RAS family genes play essential roles in tumorigenesis, effective treatments targeting RAS-related tumors are lacking, partly because of an incomplete understanding of the complex signaling crosstalk within RAS-related tumors. Here, we performed a large-scale genetic screen in Drosophila eye imaginal discs and identified Misshapen (Msn) as a tumor suppressor that synergizes with oncogenic Ras (RasV12) to induce c-Jun N-terminal kinase (JNK) activation and Hippo inactivation, then subsequently leads to tumor overgrowth and invasion. Moreover, ectopic Msn expression activates Hippo signaling pathway and suppresses Hippo signaling disruption-induced overgrowth. Importantly, we further found that Msn acts downstream of protocadherin Fat (Ft) to regulate Hippo signaling. Finally, we identified msn as a Yki/Sd target gene that regulates Hippo pathway in a negative feedback manner. Together, our findings identified Msn as a tumor suppressor and provide a novel insight into RAS-related tumorigenesis that may be relevant to human cancer biology. |
| وصف الملف: | application/pdf |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c2efd892a650196ef6cdd7c511ea5d https://doi.org/10.3390/cells10040894 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....76c2efd892a650196ef6cdd7c511ea5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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