Whole genome sequencing of elite athletes
العنوان: | Whole genome sequencing of elite athletes |
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المؤلفون: | Oleg V. Borisov, Elena Valeeva, Liliya B Andryushchenko, Ildus I. Ahmetov, Fanis A Mavliev, Azat M Akhatov, Andrey K. Larin, Elena S. Kostryukova, Ekaterina A. Semenova, Eugenia A. Boulygina, Nikolay A. Kulemin, Edward V. Generozov, Oleg N Andryushchenko, R. M. Nabiullina, Piotr Zmijewski |
المصدر: | Biology of Sport Biology of Sport, Vol 37, Iss 3, Pp 295-304 (2020) |
بيانات النشر: | Termedia Sp. z.o.o., 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | 0301 basic medicine, Genotype, QH301-705.5, Nonsense mutation, Single-nucleotide polymorphism, Physical Therapy, Sports Therapy and Rehabilitation, 03 medical and health sciences, Athletic performance, 0302 clinical medicine, Polymorphism (computer science), Physiology (medical), Orthopedics and Sports Medicine, Allele, Biology (General), Polymorphism, Wrestling, Exome sequencing, Genetic association, Genetics, Reaction time, Original Paper, biology, Athletes, 030229 sport sciences, biology.organism_classification, 030104 developmental biology, Sports medicine, RC1200-1245 |
الوصف: | Whole genome sequencing (WGS) has great potential to explore all possible DNA variants associated with physical performance, psychological traits and health conditions of athletes. Here we present, for the first time, annotation of genomic variants of elite athletes, based on the WGS of 20 Tatar male wrestlers. The maximum number of high-quality variants per sample was over 3.8 M for single nucleotide polymorphisms (SNPs) and about 0.64 M for indels. The maximum number of nonsense mutations was 148 single nucleotide variants (SNVs) per individual. Athletes' genomes on average contained 18.9 nonsense SNPs in a homozygous state per sample, while non-athletes' exomes (Tatar controls, n = 19) contained 18 nonsense SNPs. Finally, we applied genomic data for the association analysis and used reaction time (RT) as an example. Out of 1884 known genome-wide significant SNPs related to RT, we identified four SNPs (KIF27 rs10125715, APC rs518013, TMEM229A rs7783359, LRRN3 rs80054135) associated with RT in wrestlers. The cumulative number of favourable alleles (KIF27 A, APC A, TMEM229A T, LRRN3 T) was significantly correlated with RT both in wrestlers (P = 0.0003) and an independent cohort (n = 43) of physically active subjects (P = 0.029). Furthermore, we found that the frequencies of the APC A (53.3 vs 44.0%, P = 0.033) and LRRN3 T (7.5 vs 2.8%, P = 0.009) alleles were significantly higher in elite athletes (n = 107) involved in sports with RT as an essential component of performance (combat sports, table tennis and volleyball) compared to less successful (n = 176) athletes. The LRRN3 T allele was also over-represented in elite athletes (7.5%) in comparison with 189 controls (2.9%, P = 0.009). In conclusion, we present the first WGS study of athletes showing that WGS can be applied in sport and exercise science. |
تدمد: | 0860-021X |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d6e9d7ba1f3b02bf301e2f25f3fe3b https://doi.org/10.5114/biolsport.2020.96437 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....76d6e9d7ba1f3b02bf301e2f25f3fe3b |
قاعدة البيانات: | OpenAIRE |
تدمد: | 0860021X |
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