أعرض في EDS

The MINERVA study design and rationale: a controlled randomized trial to assess the clinical benefit of minimizing ventricular pacing in pacemaker patients with atrial tachyarrhythmias

التفاصيل البيبلوغرافية
العنوان: The MINERVA study design and rationale: a controlled randomized trial to assess the clinical benefit of minimizing ventricular pacing in pacemaker patients with atrial tachyarrhythmias
المؤلفون: André Pisapia, Reinhard C. Funck, Helmut Puererfellner, Luis Mont, Giuseppe Boriani, Andrea Grammatico, Nicoletta Grovale, Carsten W. Israel, Luigi Padeletti, Raymond Tukkie, Antonis S. Manolis
المساهمون: Funck RC, Boriani G, Manolis AS, Püererfellner H, Mont L, Tukkie R, Pisapia A, Israel CW, Grovale N, Grammatico A, Padeletti L
المصدر: American heart journal. 156(3)
سنة النشر: 2008
مصطلحات موضوعية: Tachycardia, medicine.medical_specialty, Atrial Fibrillation, Cardiac Pacing, Artificial, Cardiovascular Diseases, Hospitalization, Humans, Incidence, Single-Blind Method, Atrial Function, Research Design, law.invention, Randomized controlled trial, law, Internal medicine, medicine, Stroke, Fibrillation, business.industry, Atrial fibrillation, medicine.disease, Surgery, Heart failure, Artificial, Antitachycardia Pacing, Cardiology, Cardiac Pacing, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Atrioventricular block
الوصف: Background Dual-chamber (DDD) pacing has generally been regarded as "physiologic pacing" and therefore expected to be superior to ventricular pacing. Major randomized trials have so far failed to demonstrate significant reductions in the incidences of mortality, stroke, and heart failure. It has been shown that unnecessary ventricular pacing in patients with sinus node dysfunction or only intermittent atrioventricular block is associated with ventricular desynchronization and increased risk of atrial tachyarrhythmias (ATA). Methods The MINimizE Right Ventricular pacing to prevent A trial fibrillation and heart failure (MINERVA) study is a prospective, multi-center, randomized, international, single-blind, controlled trial designed to determine whether physiologic pacing through the managed ventricular pacing (MVP) algorithm combined with preventive atrial pacing (PAP) and atrial antitachycardia pacing (ATP) is superior to standard DDD pacing in terms of 2-year reduction in death, permanent ATA, and cardiovascular hospitalizations. Patients with standard class I or II indications for permanent DDD pacing and history of ATA will receive a Medtronic EnRhythm implantable pacemaker (Medtronic, Minneapolis, MN). After a 1-month run-in period, patients will be randomized in a 1:1:1 manner to the DDD (control group, all OFF), the DDDRP (MVP + PAP + ATP ON), and the MVP group (only MVP ON). Up to 1,300 patients will be included in approximately 70 centers in Europe, the Middle East, and Asia. Conclusions The MINERVA study will make an important contribution to the management of patients with paroxysmal ATA and accepted indications for dual-chamber pacemaker implantation by determining whether physiologic pacing combined with PAP and ATP is superior to standard DDD pacing in terms of reduction of mortality, incidence of permanent ATA, and cardiovascular hospitalizations.
وصف الملف: STAMPA
تدمد: 1097-6744
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77275a99b588717e8c759cabfbac5e5a
https://pubmed.ncbi.nlm.nih.gov/18760124
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....77275a99b588717e8c759cabfbac5e5a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10976744