Spermatogonial stem cell transplantation and male infertility: Current status and future directions
| العنوان: | Spermatogonial stem cell transplantation and male infertility: Current status and future directions |
|---|---|
| المؤلفون: | Connor M. Forbes, Peter N. Schlegel, Ryan Flannigan |
| المصدر: | Arab Journal of Urology, Vol 16, Iss 1, Pp 171-180 (2018) Arab Journal of Urology |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, SSC, spermatogonial stem cell, KS, Klinefelter syndrome, medicine.medical_treatment, Non-obstructive azoospermia, c-Kit, KIT Proto-oncogene receptor tyrosine kinase, ICSI, intracytoplasmic sperm injection, Intracytoplasmic sperm injection, Male infertility, 0302 clinical medicine, Onco-fertility, Allograft, Promyelocytic leukaemia zinc finger, Bcl6b, B-Cell CLL/Lymphoma 6B, Fertility preservation, Stem cell therapy, 030219 obstetrics & reproductive medicine, GDNF, glial cell line-derived neurotrophic factor, Stem-cell therapy, FISH, fluorescence in situ hybridisation, Management, Stem cell, PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses, RA(R), retinoic acid (receptor), medicine.medical_specialty, endocrine system, PLZF, promyelocytic leukaemia zinc finger, Urology, ID4, inhibitor of differentiation 4, 03 medical and health sciences, FGF2, Fibroblast growth factor 2, Internal medicine, medicine, ART, assisted reproductive technologies, business.industry, SPG, spermatogonia, BMP4, bone morphogenetic protein 4, medicine.disease, Diseases of the genitourinary system. Urology, Transplantation, ZBTB, zinc finger and broad complex/Tramtrack/bric-a-brac, 030104 developmental biology, Preferred reporting items for systematic reviews and meta-analyses, PGC, primordial germ cells, Stra8, stimulated by RA 8, RC870-923, business, CD(24)(34), cluster of differentiation (24)(34) |
| الوصف: | Objective: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. Materials and methods: We performed a search for publications addressing spermatogonial stem cell transplantation in the treatment of male infertility. The search engines PubMed and Google Scholar were used from 1990 to 2017. Search terms were relevant for spermatogonial stem cell therapies. Titles of publications were screened for relevance; abstracts were read, if related and full papers were reviewed for directly pertinent original research. Results: In all, 58 papers were found to be relevant to this review, and were included in appropriate subheadings. This review discusses the various techniques that SSCs are being investigated to treat forms of male infertility. Conclusions: Evidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research. Keywords: Non-obstructive azoospermia, Fertility preservation, Onco-fertility, Male infertility, Stem cell therapy, Allograft |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7746cf3ff82a15445022c330c01127ea http://www.sciencedirect.com/science/article/pii/S2090598X17301493 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7746cf3ff82a15445022c330c01127ea |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |