Biomaterials for mRNA delivery
| العنوان: | Biomaterials for mRNA delivery |
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| المؤلفون: | Yingjie Xu, Harshal Zope, Bruce R. Zetter, Mohammad Ariful Islam, Emma Reesor, Jinjun Shi |
| المصدر: | Biomaterials Science. 3:1519-1533 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Messenger RNA, Host genome, Innate immune system, Genetic Vectors, Gene Transfer Techniques, Biomedical Engineering, RNA, Biocompatible Materials, Biological Transport, Transfection, Biology, Bioinformatics, Article, Cell biology, Clinical Practice, chemistry.chemical_compound, chemistry, Humans, Nanotechnology, General Materials Science, RNA, Messenger, DNA, Enzymatic degradation |
| الوصف: | Messenger RNA (mRNA) has recently emerged with remarkable potential as an effective alternative to DNA-based therapies because of several unique advantages. mRNA does not require nuclear entry for transfection activity and has a negligible chance of integrating into the host genome which excludes the possibility of potentially detrimental genomic alternations. Chemical modification of mRNA has further enhanced its stability and decreased its activation of innate immune responses. Additionally, mRNA has been found to have rapid expression and predictable kinetics. Nevertheless, the ubiquitous application of mRNA remains challenging given its unfavorable attributes, such as large size, negative charge and susceptibility to enzymatic degradation. Further refinement of mRNA delivery modalities is therefore essential for its development as a therapeutic tool. This review provides an exclusive overview of current state-of-the-art biomaterials and nanotechnology platforms for mRNA delivery, and discusses future prospects to bring these exciting technologies into clinical practice. |
| تدمد: | 2047-4849 2047-4830 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776d40c68e92eaefa65cafb2985d32f4 https://doi.org/10.1039/c5bm00198f |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....776d40c68e92eaefa65cafb2985d32f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474849 20474830 |
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