FCRL4 Is an Fc Receptor for Systemic IgA, but Not Mucosal Secretory IgA
| العنوان: | FCRL4 Is an Fc Receptor for Systemic IgA, but Not Mucosal Secretory IgA |
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| المؤلفون: | Leslie Y. T. Leung, Srijit Khan, Nikolaus E. Wolter, Götz R. A. Ehrhardt, Yanling Liu, Evan J. Propst, Sofiya Goroshko, Paolo Campisi, Shilan Dong, Eyal Grunebaum |
| المصدر: | The Journal of Immunology. 205:533-538 |
| بيانات النشر: | The American Association of Immunologists, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | IgA binding, Bodily Secretions, Hot Temperature, Secretory component, Immunology, Fc receptor, Receptors, Fc, law.invention, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, law, Cell Adhesion, Humans, Immunology and Allergy, Secretory IgA, Receptor, B-Lymphocytes, Mucous Membrane, biology, Chemistry, Receptor Aggregation, Molecular biology, Immunoglobulin A, HEK293 Cells, Lymphatic system, biology.protein, Recombinant DNA, Immunologic Memory, Function (biology), Protein Binding, Signal Transduction, 030215 immunology |
| الوصف: | Fc receptor–like (FCRL) 4 is an immunoregulatory receptor expressed on a subpopulation of human memory B cells of mucosa-associated lymphoid tissue. Fc receptor function of FCRL4 was demonstrated by binding of IgA to FCRL4 following heat aggregation of the Ig. In this study, we demonstrate that FCRL4 recognizes J chain–linked systemic IgA in the absence of heat aggregation. We further demonstrate that mucosal secretory IgA is not recognized by FCRL4 and that systemic IgA binding can be competitively inhibited by recombinant secretory component protein. Finally, we provide evidence that primary FCRL4-bearing human memory B cells are constitutively bound to IgA. Our study provides a mechanism for the negative regulatory activity of FCRL4 on AgR-mediated B cell activation. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::776e169845250bb0ab659f2df5a3d0ed https://doi.org/10.4049/jimmunol.2000293 |
| رقم الأكسشن: | edsair.doi.dedup.....776e169845250bb0ab659f2df5a3d0ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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