Pharmacokinetics and pharmacodynamics of ramipril and piretanide administered alone and in combination
| العنوان: | Pharmacokinetics and pharmacodynamics of ramipril and piretanide administered alone and in combination |
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| المؤلفون: | Kurt Löffler, G. Ruf, N. de la Rey, S. Gera, H. G. Luus, W. Schulz, Dietmar Trenk, E. Jähnchen |
| المصدر: | European Journal of Clinical Pharmacology. 46:545-550 |
| بيانات النشر: | Springer Science and Business Media LLC, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Male, Pharmacology, Ramipril, Sulfonamides, Cross-Over Studies, Piretanide, General Medicine, Crossover study, chemistry.chemical_compound, Pharmacokinetics, chemistry, Oral administration, Pharmacodynamics, Healthy volunteers, medicine, Humans, Drug Therapy, Combination, Single-Blind Method, Pharmacology (medical), Single blind, Diuretics, medicine.drug |
| الوصف: | The pharmacokinetics and pharmacodynamics of single oral doses of 5 mg ramipril and 6 mg piretanide administered separately and in combination were determined in a single blind, randomised, 3-period cross-over study in 24 healthy male volunteers. The peak plasma concentrations of ramipril and ramiprilat increased slightly (from 11.9 to 14.8 ng/ml, and from 6.39 to 8.96 ng/ml, respectively) as did the area under the plasma concentration-time curve of ramipril (0-4 h) and ramiprilat (0-24 h) (from 15.8 to 19.8 ng.ml-1.h, and from 63.4 to 74.6 ng.ml-1.h, respectively). The urinary excretion of ramiprilat also rose (from 6.82 to 7.73% of dose) following simultaneous treatment with piretanide. These effects were probably due to reduced first-pass metabolism of ramipril/ramiprilat to inactive metabolites. The blood pressure lowering effect, the time course of inhibition of ACE activity in plasma and the concentration-response relationship for the inhibition of plasma ACE activity were not affected by piretanide. The peak plasma concentration of piretanide was somewhat reduced (from 285 to 244 ng/ml) following simultaneous treatment with ramipril. No other pharmacokinetic parameter was affected. Piretanide increased urine flow, and sodium, chloride and potassium excretion, especially during the first 2 hours following administration. These pharmacodynamic parameters were not affected by ramipril. Thus, simultaneous administration of single oral doses of ramipril and piretanide caused modest changes in the peak and average plasma concentrations of both drugs, which did not lead to detectable alterations in the pharmacodynamic parameters measured in healthy volunteers. |
| تدمد: | 1432-1041 0031-6970 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77861a03a159d22c5f8d1cf99cef47bc https://doi.org/10.1007/bf00196113 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....77861a03a159d22c5f8d1cf99cef47bc |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321041 00316970 |
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