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The clinicopathological roles of alpha-B-crystallin and p53 expression in patients with head and neck squamous cell carcinoma

التفاصيل البيبلوغرافية
العنوان: The clinicopathological roles of alpha-B-crystallin and p53 expression in patients with head and neck squamous cell carcinoma
المؤلفون: Newell W. Johnson, Stephen R. Weinstein, Jin Gao, Karin Boslooper, Alfred King-Yin Lam
المصدر: Pathology. 40:500-504
بيانات النشر: Elsevier BV, 2008.
سنة النشر: 2008
مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Alpha B-Crystallin, Pathology and Forensic Medicine, stomatognathic system, Biomarkers, Tumor, otorhinolaryngologic diseases, Humans, Medicine, In patient, Head and neck, P53 expression, business.industry, Poorly differentiated, alpha-Crystallin B Chain, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Head and neck squamous-cell carcinoma, eye diseases, stomatognathic diseases, Head and Neck Neoplasms, Carcinoma, Squamous Cell, Female, sense organs, Tumor Suppressor Protein p53, business, Positive staining
الوصف: SummaryAims: The aim of the study was to investigate the expression of alpha-B-crystallin and p53 in head and neck squamous cell carcinoma (HNSCC).Methods: Alpha-B-crystallin and p53 expressions from 118 HNSCC were studied by immunohistochemistry and correlated with clinicopathological parameters.Results: Alpha-B-crystallin expression was seen in 28% (n = 33) of HNSCC. All except one poorly differentiated HNSCC were negative for alpha-B-crystallin. p53 expression was seen in 63% (n = 73) of HNSCC and was more common in moderately/poorly differentiated HNSCC (p = 0.034). The proportion of cases with positive staining for either alpha-B-crystallin or p53 was different in different anatomical locations in the head and neck. Patients with HNSCC having a high portion of tumour cells expressing p53 had a shorter survival than the other groups (p = 0.032).Conclusion: The expression of p53 and alpha-B-crystallin were related to the differentiation and site of the HNSCC. Alpha-B-crystallin was not a prognostic mar...
تدمد: 0031-3025
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7786f93806d4ef3a6316b0aebcfb8852
https://doi.org/10.1080/00313020802198010
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....7786f93806d4ef3a6316b0aebcfb8852
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00313025