Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study
| العنوان: | Synaptic Efficacy as a Function of Ionotropic Receptor Distribution: A Computational Study |
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| المؤلفون: | Jean-Marie C. Bouteiller, Serge Bischoff, Michel Baudry, Theodore W. Berger, Sushmita L. Allam, Nicolas Ambert, Renaud Greget, Eric Y. Hu |
| المصدر: | PLoS ONE PLoS ONE, Vol 10, Iss 10, p e0140333 (2015) |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Models, Neurological, Neural facilitation, lcsh:Medicine, Glutamic Acid, Hippocampus, Receptors, N-Methyl-D-Aspartate, Synaptic augmentation, Metaplasticity, Animals, Humans, Computer Simulation, Receptors, AMPA, lcsh:Science, Multidisciplinary, Synaptic scaling, Chemistry, lcsh:R, Synaptic fatigue, Biochemistry, Synaptic plasticity, Synapses, lcsh:Q, Synaptic tagging, Neuroscience, Ion channel linked receptors, Research Article |
| الوصف: | Glutamatergic synapses are the most prevalent functional elements of information processing in the brain. Changes in pre-synaptic activity and in the function of various post-synaptic elements contribute to generate a large variety of synaptic responses. Previous studies have explored postsynaptic factors responsible for regulating synaptic strength variations, but have given far less importance to synaptic geometry, and more specifically to the subcellular distribution of ionotropic receptors. We analyzed the functional effects resulting from changing the subsynaptic localization of ionotropic receptors by using a hippocampal synaptic computational framework. The present study was performed using the EONS (Elementary Objects of the Nervous System) synaptic modeling platform, which was specifically developed to explore the roles of subsynaptic elements as well as their interactions, and that of synaptic geometry. More specifically, we determined the effects of changing the localization of ionotropic receptors relative to the presynaptic glutamate release site, on synaptic efficacy and its variations following single pulse and paired-pulse stimulation protocols. The results indicate that changes in synaptic geometry do have consequences on synaptic efficacy and its dynamics. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779433b84c94ccf3393182012afe3437 https://pubmed.ncbi.nlm.nih.gov/26480028 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....779433b84c94ccf3393182012afe3437 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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