They live in the land down under: thyroid function and basal metabolic rate in theBlind Mole Rat, Spalax
| العنوان: | They live in the land down under: thyroid function and basal metabolic rate in theBlind Mole Rat, Spalax |
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| المؤلفون: | Aaron Avivi, Nick Sotnichenko, Osnat Ashur-Fabian, Keren Cohen, Paul J. Davis, Mark Band, Eviatar Nevo, Aleck Hercbergs, Martin Ellis |
| المصدر: | Endocrine Research. 39:80-85 |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Spalax, Thyroid Gland, Captivity, Zoology, Environment, Biology, Hemoglobins, Osmoregulation, Oxygen Consumption, Endocrinology, Species Specificity, Serum free, Mole, medicine, Animals, Israel, Hypoxia, Ecology, Thyroid, Humidity, General Medicine, biology.organism_classification, Mice, Inbred C57BL, Thyroxine, medicine.anatomical_structure, Hematocrit, Basal metabolic rate, Triiodothyronine, Female, Basal Metabolism, Seasons, Thyroid function, Hormone |
| الوصف: | The Israeli blind subterranean mole rat (Spalax ehrenbergi superspecies) lives in sealed underground burrows under extreme, hypoxic conditions. The four Israeli Spalax allospecies have adapted to different climates, the cool-humid (Spalax galili, 2 n = 52 chromosomes), semihumid (S. golani, 2 n = 54) north regions, warm-humid (S. carmeli, 2 n = 58) central region and the warm-dry S. judaei, 2 n = 60) southern regions. A dramatic interspecies decline in basal metabolic rate (BMR) from north to south, even after years of captivity, indicates a genetic basis for this BMR trait. We examined the possibility that the genetically-conditioned interspecies BMR difference was expressed via circulating thyroid hormone. An unexpected north to south increase in serum free thyroxine (FT4) and total 3, 5, 3'-triiodo-L-thyronine (T3) (p 0.02) correlated negatively with previously published BMR measurements. The increases in serum FT4 and T3 were symmetrical, so that the T3:FT4 ratio - interpretable as an index of conversion of T4 to T3 in nonthyroidal tissues - did not support relative decrease in production of T3 as a contributor to BMR. Increased north-to-south serum FT4 and T3 levels also correlated negatively with hemoglobin/hematocrit. North-to-south adaptations in spalacids include decreased BMR and hematocrit/hemoglobin in the face of increasing thyroid hormone levels, arguing for independent control of hormone secretion and BMR/hematocrit/hemoglobin. But the significant inverse relationship between thyroid hormone levels and BMR/hematocrit/hemoglobin is also consistent with a degree of cellular resistance to thyroid hormone action that protects against hormone-induced increase in oxygen consumption in a hostile, hypoxic environment. |
| تدمد: | 1532-4206 0743-5800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7798b38ce336b196ec80749e8046622d https://doi.org/10.3109/07435800.2013.833216 |
| رقم الأكسشن: | edsair.doi.dedup.....7798b38ce336b196ec80749e8046622d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15324206 07435800 |
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