ACTIVATE: the effect of aclidinium/formoterol on hyperinflation, exercise capacity, and physical activity in patients with COPD
| العنوان: | ACTIVATE: the effect of aclidinium/formoterol on hyperinflation, exercise capacity, and physical activity in patients with COPD |
|---|---|
| المؤلفون: | Massimo Notari, Eduard Molins, Pierluigi Paggiaro, Judith Garcia-Aymerich, Esther Garcia Gil, Thierry Troosters, Henrik Watz, Diana Jarreta, Kai M. Beeh, Antonio Zapata |
| المصدر: | Recercat. Dipósit de la Recerca de Catalunya instname International Journal of Chronic Obstructive Pulmonary Disease Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | Dove Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Time Factors, Functional Residual Capacity, Aclidinium, Hyperinflation, Inspiratory Capacity, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Functional residual capacity, Formoterol Fumarate, Formoterol, 030212 general & internal medicine, Lung, Malalties pulmonars obstructives cròniques, Original Research, COPD, Exercise Tolerance, Health Policy, General Medicine, Middle Aged, Dry-powder inhaler, Bronchodilator Agents, Europe, Drug Combinations, Treatment Outcome, Anesthesia, Female, Public Health, medicine.drug, Pulmonary and Respiratory Medicine, Canada, Physical activity, Muscarinic Antagonists, International Journal of Chronic Obstructive Pulmonary Disease, Placebo, 03 medical and health sciences, Double-Blind Method, Exercise capacity, medicine, Humans, Chronic obstructive pulmonary diseases, Adrenergic beta-2 Receptor Agonists, Exercise, Aged, business.industry, Environmental and Occupational Health, Recovery of Function, Physical fitness, medicine.disease, 030228 respiratory system, Public Health, Environmental and Occupational Health, business, Tropanes, Condició física |
| الوصف: | Henrik Watz,1 Thierry Troosters,2 Kai M Beeh,3 Judith Garcia-Aymerich,4–6 Pierluigi Paggiaro,7 Eduard Molins,8 Massimo Notari,9 Antonio Zapata,10 Diana Jarreta,8 Esther Garcia Gil8 1Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany; 2Department of Rehabilitation Sciences, Pulmonary Rehabilitation and Respiratory Division, University Hospital Leuven, KU Leuven, Leuven, Belgium; 3insaf Respiratory Research Institute GmbH, Wiesbaden, Germany; 4Barcelona Institute of Global Health (ISGlobal), Barcelona, Spain; 5Universitat Pompeu Fabra (UPF), Barcelona, Spain; 6CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; 7Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy; 8AstraZeneca PLC, Barcelona, Spain; 9A. Menarini Farmaceutica Internazionale S.R.L., Firenze, Italy; 10Laboratorios Menarini, S.A., Badalona, Spain Abstract: The Phase IV, 8-week, randomized, double-blind, placebo-controlled ACTIVATE study (NCT02424344) evaluated the effect of aclidinium/formoterol (AB/FF) 400/12µg twice daily on lung hyperinflation, exercise capacity, and physical activity in patients with moderate-to-severe COPD. Patients received AB/FF (n=134) or placebo (n=133) (1:1) via the Genuair™/Pressair® dry powder inhaler for 8 weeks. From Weeks 5 to 8, all patients participated in behavioral intervention (BI; daily messages providing step goals). The primary end point was trough functional residual capacity (FRC) at Week4. Exercise endurance time and physical activity were assessed at Week4 (pharmacotherapy only) and at Week8 (8 weeks of pharmacotherapy plus 4 weeks of BI). Other end points included post-dose FRC, residual volume, and inspiratory capacity (IC) at rest and during exercise. After 4 weeks, trough FRC improved with AB/FF versus placebo but did not reach significance (125 mL; P=0.0690). However, post-dose FRC, residual volume, and IC at rest improved significantly with AB/FF at Week4 versus placebo (all P |
| وصف الملف: | application/pdf; text/html; Electronic-eCollection |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f11794cc07563b0abfd25c0490d458 http://hdl.handle.net/2445/116223 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....77f11794cc07563b0abfd25c0490d458 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |