The therapeutic potential of berberine chloride against SARM1 ‐dependent axon degeneration in acrylamide‐induced neuropathy
| العنوان: | The therapeutic potential of berberine chloride against |
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| المؤلفون: | Shuai Wang, Yifan Zhang, Jianwei Lou, Hui Yong, Shulin Shan, Zhidan Liu, Mingxue Song, Cuiqin Zhang, Ruirui Kou, Zhaoxiong Liu, Wenhao Yu, Xiulan Zhao, Fuyong Song |
| المصدر: | Phytotherapy Research. 37:77-88 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Pharmacology |
| الوصف: | Chronic acrylamide (ACR) intoxication causes typical pathology of axon degeneration. Moreover, sterile-α and toll/interleukin 1 receptor motif-containing protein 1 (SARM1), the central executioner of the programmed axonal destruction process under various insults, is up-regulated in ACR neuropathy. However, it remains unclear whether inhibitors targeting SARM1 are effective or not. Among all the pharmacological antagonists, berberine chloride (BBE), a natural phytochemical and the first identified non-competitive inhibitor of SARM1, attracts tremendous attention. Here, we observed the protection of 100 μM BBE against ACR-induced neurites injury (2 mM ACR, 24 hr) in vitro, and further evaluated the neuroprotective effect of BBE (100 mg/kg p.o. three times a week for 4 weeks) in ACR-intoxicated rats (40 mg/kg i.p. three times a week for 4 weeks). The expression of SARM1 was also detected. BBE intervention significantly inhibited the overexpression of SARM1, ameliorated axonal degeneration, alleviated pathological changes in the sciatic nerve and spinal cord, and improved neurobehavioral symptoms in ACR-poisoned rats. Thus, BBE exhibits a strong neuroprotective effect against the SARM1-dependent axon destruction in ACR neuropathy. Meanwhile, our study underscores the need for appropriate inhibitor selection in diverse situations that would benefit from blocking the SARM1-dependent axonal destruction pathway. |
| تدمد: | 1099-1573 0951-418X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781d3b4b443d6d116d3d5b6a125295ce https://doi.org/10.1002/ptr.7594 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....781d3b4b443d6d116d3d5b6a125295ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991573 0951418X |
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