Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues
| العنوان: | Investigation of the effects of three different generations of fluoroquinolone derivatives on antioxidant and immunotoxic enzyme levels in different rat tissues |
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| المؤلفون: | Abdulahad Dogan, Fatih Donmez |
| المصدر: | Drug and Chemical Toxicology. 45:2686-2698 |
| بيانات النشر: | Informa UK Limited, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Antioxidant, Adenosine Deaminase, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Moxifloxacin, Levofloxacin, Pharmacology, Toxicology, Antioxidants, Lipid peroxidation, Superoxide dismutase, Nalidixic Acid, chemistry.chemical_compound, Ciprofloxacin, Malondialdehyde, medicine, Animals, Aspartate Aminotransferases, Rats, Wistar, Triglycerides, Peroxidase, chemistry.chemical_classification, Glutathione Peroxidase, Chemical Health and Safety, biology, SARS-CoV-2, Superoxide Dismutase, Chemistry, Glutathione peroxidase, Public Health, Environmental and Occupational Health, COVID-19, General Medicine, Glutathione, Catalase, Rats, Oxidative Stress, Glucose, Creatinine, Myeloperoxidase, biology.protein, Lipid Peroxidation, Fluoroquinolones, medicine.drug |
| الوصف: | Fluoroquinolones (FQs) are synthetic and broad-spectrum antimicrobial drugs derived from nalidixicacid. FQs are used against SARS-CoV-2 in our country, and for the treatment of some urinary tract diseases, gastrointestinal diseases, respiratory tract diseases, sexually transmitted diseases, and dermatological diseases. The present study investigated the effect of 1-,7-,14-day treatments of three differentFQ derivatives; ciprofloxacin (CIP) 80 mg/kg/day, levofloxacin (LVX) 40 mg/kg/day, and moxifloxacin(MXF) 40mg/kg/day, on biochemical parameters, lipid peroxidation, antioxidant enzymes, and immunotoxicity. 72 Wistar albino male rats were distributed to four groups including 18 rats in each group and were sacrificed on three different time points. The 14-day treatment of MXF significantly reduced the levels of aspartate aminotransferase (AST), glucose, reduced glutathione (GSH), malondialdehyde (MDA), catalase (CAT), myeloperoxidase (MPO), adenosine deaminase (ADA), and glutathione peroxidase (GPx). Furthermore, 14-day treatment of LVX increased liver [GSH, MPO, ADA, superoxide dismutase (SOD)], and GSH (erythrocyte) levels; whereas it significantly reduced the levels of AST, TG (triglycerides) and associated parameters levels in all the tissues (MDA), erythrocytes, and liver (MPO, CAT, SOD, GPx). After 14-day treatment of CIP; the erythrocyte levels of GSH, MPO, GPx, and CAT significantly decreased; whereas the levels of glucose, creatinine, MPO (liver), and GST (kidney and erythrocyte) significantly increased. It has been concluded that FQ derivatives used in this experiment did not display any correlation in terms of the efficacies in the different time points and tissues. Thus, it is recommended to use such FQ derivatives considering the duration of use and target tissue. |
| تدمد: | 1525-6014 0148-0545 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e32cc0f363a194f7bef613faa54339 https://doi.org/10.1080/01480545.2021.1982624 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....78e32cc0f363a194f7bef613faa54339 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15256014 01480545 |
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