Validity of the Cold Pressor Test and Pain Sensitivity Questionnaire via online self-administration
| العنوان: | Validity of the Cold Pressor Test and Pain Sensitivity Questionnaire via online self-administration |
|---|---|
| المؤلفون: | Matthew H McIntyre, 23andMe Research Team, Achim Kless, Peter Hein, Mark Field, Joyce Y Tung |
| المصدر: | PLoS ONE PLoS ONE, Vol 15, Iss 4, p e0231697 (2020) |
| بيانات النشر: | Cold Spring Harbor Laboratory, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Questionnaires, Male, Physiology, Sensory Physiology, Social Sciences, Hands, Controlled studies, Pathology and Laboratory Medicine, 0302 clinical medicine, 030202 anesthesiology, Surveys and Questionnaires, Internal consistency, Medicine and Health Sciences, Psychology, Computer Networks, Musculoskeletal System, Statistic, Pain Measurement, Sex Characteristics, Multidisciplinary, Pharmaceutics, Cold pressor test, Middle Aged, Sensory Systems, Cold Temperature, Arms, Nociception, Somatosensory System, Research Design, Neuropathic pain, Cohort, Medicine, Female, Anatomy, Self-administration, Research Article, Adult, Pain Threshold, Computer and Information Sciences, medicine.medical_specialty, Psychometrics, Science, Lower Back Pain, Pain, Research and Analysis Methods, 03 medical and health sciences, Young Adult, Signs and Symptoms, Sex Factors, Drug Therapy, Diagnostic Medicine, Threshold of pain, medicine, Criterion validity, Humans, Neuropathic Pain, Aged, Internet, Survey Research, business.industry, Biology and Life Sciences, Pain Sensation, Construct validity, Body Limbs, Physical therapy, business, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | To determine the feasibility of complex home-based phenotyping, 1,876 research participants from the customer base of 23andMe participated in an online version of a Pain Sensitivity Questionnaire (PSQ) as well as a cold pressor test (CPT) which is used in clinical assessments of pain. Overall our online version of the PSQ performed similarly to the original pen-and-paper version. Construct validity of the PSQ total was demonstrated by internal consistency and consistent discrimination between more and less painful items. Criterion validity was demonstrated by correlation with pain sensitivity as measured by the cold pressor test. Within the same cohort we performed a cold pressor test using a layperson description and household equipment. Comparison with published reports from controlled studies revealed similar distributions of cold pain tolerance times (i.e., time elapsed before removing the hand from the water). Of those who elected to participate in the CPT, a large majority of participants did not report issues with the test procedure or noncompliance to the instructions (97%). We confirmed a large sex difference in CPT thresholds in line with published data, such that women removed their hands from the water at a median of 54.2 seconds, with men lasting for a median time of 82.7 seconds (Kruskal-Wallis statistic, p < 0.0001), but other factors like age or current pain treatment were at most weakly associated, and inconsistently between men and women. We introduce a new paradigm for performing pain testing, called testing@home, that, in the case of cold nociception, showed comparable results to studies conducted under controlled conditions and supervision of a health care professional.SummaryResearch paradigms employing home-based phenotyping are feasible, with both questionnaires and self-administration of a well-established experimental human pain model yielding similar results compared to controlled settings. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7952ac1486fb77477bdf514ceb79fd7a https://doi.org/10.1101/19011775 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7952ac1486fb77477bdf514ceb79fd7a |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |