أعرض في EDS

ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer

التفاصيل البيبلوغرافية
العنوان: ZG16 regulates PD-L1 expression and promotes local immunity in colon cancer
المؤلفون: Wencai Li, Enjie Liu, Yi Ding, Hui Meng, Liang Wang
المصدر: Translational Oncology, Vol 14, Iss 2, Pp 101003-(2021)
Translational Oncology
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Colorectal cancer, medicine.medical_treatment, Zg16, Colon carcinoma, Disease, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, Immune system, PD-L1, medicine, zg16, Zymogen granule protein 16, Nk cell, Original Research, crc, Colorectal cance, biology, business.industry, ihc, immunohistochemistry, Immunotherapy, MSI, microsatellite instability, medicine.disease, NKG2D, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, digestive system diseases, 030104 developmental biology, Lymphatic system, Oncology, 030220 oncology & carcinogenesis, Pd-l1, biology.protein, Cancer research, Biomarker (medicine), business
الوصف: Highlights • ZG16 is negatively correlated to PD-L1 expression in patient with CRC. • ZG16 blocks PD-L1 expression to modulate immune response in colon cancer. • Overexpression of ZG16 promotes NK cells survival and proliferation. • ZG16 overexpression inhibits in vivo SW480 xenograft tumor growth.
CRC is a heterogeneous disease due to global molecular alterations, including mismatch-repair-deficient (dMMR) and microsatellite instability-high (MSI-H). Immunotherapy has achieved durable responses in a subset of patients with dMMR-MSI-H metastatic CRC. It has been showed that Loss of ZG16 is highly associated with colorectal cancer. However, whether ZG16 modulates tumor immunity in colorectal cancer is unclear. In this study, we demonstrated that the expression of ZG16 is associated with distant metastasis and lymphatic invasive in colorectal cancer. Besides, ZG16 is negatively correlated to PD-L1 expression in patient with CRC and overexpression of ZG16 blocks PD-L1 expression in colorectal cancer cells. In addition, overexpression of ZG16 promotes NK cells survival and proliferation, which is dependent on NKG2D expression. Our data demonstrate that ZG16 plays a role in modulation of immune response in colorectal cancer. The strong correlation between ZG16 and PD-L1 suggests that ZG16 may serve a biomarker to stratify patient who will benefit from immunotherapy.
اللغة: English
تدمد: 1936-5233
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e79773d137549ce24484b9179d6571
http://www.sciencedirect.com/science/article/pii/S1936523320304952
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....79e79773d137549ce24484b9179d6571
قاعدة البيانات: OpenAIRE
الوصف
تدمد:19365233