Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy
| العنوان: | Analysis of biochemical markers in the saliva and correlation with clinical parameters in patients with aggressive periodontitis, before and after the therapy |
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| المؤلفون: | Marko Popović, Radmila Obradović, Zana Popovic, Ivan Dozic, Branko Dozic |
| المصدر: | Srpski Arhiv za Celokupno Lekarstvo, Vol 149, Iss 3-4, Pp 142-148 (2021) |
| بيانات النشر: | National Library of Serbia, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Saliva, chemistry.chemical_element, Calcium, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Internal medicine, medicine, Aggressive periodontitis, 030212 general & internal medicine, chemistry.chemical_classification, saliva, biology, business.industry, Calculus (dental), Acid phosphatase, General Medicine, medicine.disease, intracellular enzymes, aggressive periodontitis, 3. Good health, Enzyme, chemistry, biology.protein, Medicine, Alkaline phosphatase, business, Progressive disease |
| الوصف: | Introduction/Objective. Aggressive periodontitis (AP) is a progressive disease that leads damage to periodontal tissues. The aim of the study was the analysis of intracellular enzymes: aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), acid phosphatase (ACP) and electrolytes in the saliva of patients with AP and their correlation with clinical parameters before and after the therapy. Methods. The study included 30 patients with AP (experimental group) and 35 patients with healthy parodontium (control group). Intracellular enzymes and electrolytes were analyzed in an unstimulated saliva of subjects with AP, before and after the therapy and in saliva of the control group. The analysis of biochemical markers was carried out using kinetic methods with commercial reagents. Results. Concentrations of the biochemical markers AST (28.18 ± 25.16), ALT (5.48 ± 5.14), ALP (31.13 ± 37.79), ACP (17.53 ± 14.77), calcium (2.80 ± 1.97), phosphate (4.43 ± 1.92) in the saliva of subjects of the experimental group were statistically significantly higher in relation to the control group (p = 0.000; p = 0.001). Significant correlation was found between AST values, debris index (ρ = -0.444; p = 0.026) and calculus index (ρ = -0.513; p = 0.009), and between the plaque index and ALP level in the saliva after therapy (p = 0.020). Conclusion. The investigation will contribute to a better understanding and standardization of biomarkers in the saliva that mayhelp in diagnosing the AP and evaluation of the applied therapy. |
| تدمد: | 2406-0895 0370-8179 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a35cf0d5ea39fd0b890e944c245ec03 https://doi.org/10.2298/sarh200205103p |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7a35cf0d5ea39fd0b890e944c245ec03 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24060895 03708179 |
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