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Difference in risk factors of silent brain infarction between paroxysmal and persistent atrial fibrillation

التفاصيل البيبلوغرافية
العنوان: Difference in risk factors of silent brain infarction between paroxysmal and persistent atrial fibrillation
المؤلفون: Tomotaka Yoshiyama, Shinichi Iwata, Minoru Yoshiyama, Shinichi Nonin, Asahiro Ito, Masanori Matsuo, Yasuhiro Izumiya, Andrew T. Kim, Soichiro Tamura, Sera Ishikawa
المصدر: International Journal of Cardiology: Heart & Vasculature, Vol 33, Iss, Pp 100753-(2021)
International Journal of Cardiology. Heart & Vasculature
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: medicine.medical_specialty, medicine.medical_treatment, Catheter ablation, LAA, left atrial appendage, 030204 cardiovascular system & hematology, SBI, Silent brain infarction, Asymptomatic, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, medicine, Left atrial enlargement, LA, left atrial, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, 030212 general & internal medicine, Risk factor, Silent brain infarction, Stroke, Original Paper, NVAF, nonvalvular atrial fibrillation, business.industry, eGFR, estimated glomerular filtration rate, Atrial fibrillation, DOACs, direct oral anticoagulants, medicine.disease, OR, odds ratio, Risk factors, Echocardiography, Stroke pathophysiology, RC666-701, FLAIR, fluid attenuated inversion recovery, cardiovascular system, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, MRI, magnetic resonance imaging, Kidney disease
الوصف: Highlights • Differences in risk factors for SBI between paroxysmal and persistent AF was studied. • NVAF patients (119 paroxysmal, 71 persistent) underwent brain MRI, TTE, and TEE. • DM and CKD, which represents microvascular disease, predicted SBI in paroxysmal AF. • There was no obvious therapeutic target for SBI after progression to persistent NVAF. • Intervention for DM and CKD from paroxysmal NVAF may prevent SBI and future stroke.
Background Although silent brain infarction is an independent risk factor for subsequent symptomatic stroke and dementia in patients with nonvalvular atrial fibrillation, little is known regarding differences in risk factors for silent brain infarction between patients with paroxysmal and persistent nonvalvular atrial fibrillation. Methods This study population consisted of 190 neurologically asymptomatic patients (mean age, 64 ± 11 years) with nonvalvular atrial fibrillation (119 paroxysmal, 71 persistent) who were scheduled for catheter ablation. All patients underwent brain magnetic resonance imaging to screen for silent brain infarction prior to ablation. Transthoracic and transesophageal echocardiography was performed to screen for left atrial abnormalities (left atrial enlargement, spontaneous echo contrast, or left atrial appendage emptying velocity) and complex plaques in the aortic arch. Results Silent brain infarction was detected in 50 patients (26%) [26 patients (22%) in paroxysmal vs. 24 patients (34%) in persistent, p = 0.09]. Multiple logistic regression analysis indicated that age and diabetes mellitus or chronic kidney disease (estimated glomerular filtration rate
تدمد: 2352-9067
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6b89554bcab0b16920f8c02221fb75
https://doi.org/10.1016/j.ijcha.2021.100753
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....7a6b89554bcab0b16920f8c02221fb75
قاعدة البيانات: OpenAIRE
الوصف
تدمد:23529067