Olanzapine plus carbamazepinev.carbamazepine alone in treating manic episodes
| العنوان: | Olanzapine plus carbamazepinev.carbamazepine alone in treating manic episodes |
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| المؤلفون: | Charles L. Bowden, Mauricio Tohen, Richard F. Bergstrom, Smulevich Ab, Olawale Osuntokun, Tonya Quinlan, Ferenc Martenyi, Heather S. Oliff, Waldemar Greil, Wei V. Wang, Ludmila Kryzhanovskaya |
| المصدر: | British Journal of Psychiatry. 192:135-143 |
| بيانات النشر: | Royal College of Psychiatrists, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Olanzapine, Bipolar Disorder, Adolescent, medicine.drug_class, Atypical antipsychotic, Placebo, law.invention, Benzodiazepines, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, Antimanic Agents, law, medicine, Humans, 030212 general & internal medicine, Aged, Dopamine antagonist, Mood stabilizer, Carbamazepine, Middle Aged, 030227 psychiatry, Psychiatry and Mental health, Treatment Outcome, Anesthesia, Drug Therapy, Combination, Female, medicine.symptom, Psychology, Mania, Antipsychotic Agents, medicine.drug |
| الوصف: | BackgroundCombinations of olanzapine and carbamazepine are often used in clinical practice in the management of mania.AimsTo assess the efficacy and safety of olanzapine plus carbamazepine in mixed and manic bipolar episodes.MethodRandomised, double-blind, 6-week trial of olanzapine (10–30 mg/day) plus carbamazepine (400–1200 mg/day;n=58)v.placebo plus carbamazepine (n=60) followed by open-label, 20-week olanzapine (10–30 mg/day) plus carbamazepine (400–1200 mg/day,n=86), with change in manic symptoms as main outcome measure. Safety and pharmacokinetics were also evaluated.ResultsThere were no significant differences (baseline to endpoint) in efficacy measures between treatment groups, but at 6 weeks triglyceride levels were significantly higher (P=0.008) and potentially clinically significant weight gain (⩾7%) occurred more frequently (24.6%v.3.4%,P=0.002) in the combined olanzapine and carbamazepine group. Carbamazepine reduced olanzapine concentrations but olanzapine had no effect on carbamazepine concentrations.ConclusionsThe combination of olanzapine and carbamazepine did not have superior efficacy to carbamazepine alone. The increases in weight and triglycerides observed during combination treatment are a matter of concern. |
| تدمد: | 1472-1465 0007-1250 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad6a2fbf1f5d89a66862deb6a841f5c https://doi.org/10.1192/bjp.bp.107.041301 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7ad6a2fbf1f5d89a66862deb6a841f5c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14721465 00071250 |
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