Vasorelaxant and Antihypertensive Effects of Neferine in Rats: An In Vitro and In Vivo Study
| العنوان: | Vasorelaxant and Antihypertensive Effects of Neferine in Rats: An In Vitro and In Vivo Study |
|---|---|
| المؤلفون: | Amnart Onsa-ard, Chainarong Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Piyawadee Wicha |
| المصدر: | Planta Medica. 86:496-504 |
| بيانات النشر: | Georg Thieme Verlag KG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Endothelium, Vasodilator Agents, Pharmaceutical Science, Aorta, Thoracic, Vasodilation, Pharmacology, Nitric Oxide, Benzylisoquinolines, 01 natural sciences, Analytical Chemistry, Nitric oxide, chemistry.chemical_compound, In vivo, medicine.artery, Drug Discovery, medicine, Animals, Thoracic aorta, Antihypertensive Agents, Aorta, 010405 organic chemistry, business.industry, Organic Chemistry, In vitro, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Blood pressure, medicine.anatomical_structure, Complementary and alternative medicine, chemistry, Molecular Medicine, Endothelium, Vascular, business |
| الوصف: | The present study was performed to examine the antihypertensive effect of neferine in hypertensive rats and its relaxant mechanisms in isolated rat thoracic aorta. The antihypertensive effect was evaluated by tail-cuff methods on NG-nitro-L-arginine methyl ester (L-NAME) (40 mg/kg BW) 4-week hypertensive-induced hypertensive rats. The vasorelaxant effect and its mechanisms were studied by the organ bath technique in the thoracic aorta isolated from normotensive rats. The results indicated that the treatment of neferine (1 mg/kg and 10 mg/kg) markedly decreased the systolic blood pressure (SBP) when compared with the hypertension group (137.75 ± 10.14 mmHg and 132.23 ± 9.5 mmHg, respectively, p |
| تدمد: | 1439-0221 0032-0943 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad94c8cb8a71b859f794a0582879e59 https://doi.org/10.1055/a-1123-7852 |
| رقم الأكسشن: | edsair.doi.dedup.....7ad94c8cb8a71b859f794a0582879e59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390221 00320943 |
|---|