Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer
| العنوان: | Identification of relevant prognostic values of cytokeratin 20 and cytokeratin 7 expressions in lung cancer |
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| المؤلفون: | Rong-Cheng Luo, Wei-Guang Gu, Hai-Tao Luo, Cai-Xia Liang |
| المصدر: | Bioscience Reports |
| بيانات النشر: | Portland Press Ltd., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, survival outcome, Pathology, Lung Neoplasms, Keratin-20, Biochemistry, 0302 clinical medicine, Research Articles, CK20, Middle Aged, Prognosis, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Immunohistochemistry, Adenocarcinoma, Female, Research Article, Adult, medicine.medical_specialty, CK7, Biophysics, Adenocarcinoma of Lung, 03 medical and health sciences, Cytokeratin, Biomarkers, Tumor, medicine, Humans, Lung cancer, Molecular Biology, Survival analysis, Aged, Neoplasm Staging, business.industry, Keratin 20, Keratin-7, Cell Biology, medicine.disease, Survival Analysis, lung cancer, 030104 developmental biology, Keratin 7, Immunology, T-stage, business, Follow-Up Studies |
| الوصف: | Lung cancer is one of the most common malignant tumors harmful to human health. Cytokeratin (CK) is highly conserved and differentiated related to the proliferation and differentiation of epithelial cells. The aim of the study was to explore expressions of CK20 and CK7 and corresponding prognostic values in patients with lung cancer. Our study included 258 cases of patients confirmed with lung cancer. Expressions of CK20 and CK7 mRNA and protein were detected using real-time quantitative PCR (qRT-PCR) and Western blot, respectively, followed by the performance of immunohistochemistry staining. Associations of CK20 and CK7 with the clinical parameters and prognosis of lung cancer patients were further analyzed. There were obvious differences regarding the positive expression of CK20 in different T stage, lymph node metastasis, invasion, size, and clinical stage subgroups; besides, significant differences in the positive expression of CK7 were also observed in subgroups of different sex, age, lymph node metastasis, invasion, and differentiation. Furthermore, effects of age, smoking, T stage, lymph node metastasis and invasion, size, and CK7 expressions were significant on the survival of patients (all P0.05). Positive CK20 and CK7 expressions are detected in patients with lung cancer; positive expression of CK7 associated with pathological features of lymph node metastasis and T stage may be independent clinical parameters for poor prognosis of patients with lung cancer. |
| تدمد: | 1573-4935 0144-8463 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1bf949a9b50119282717aaa1928760 https://doi.org/10.1042/bsr20171086 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7b1bf949a9b50119282717aaa1928760 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15734935 01448463 |
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