F133. A LONGITUDINAL COMPARISON OF TWO NEUROCOGNITIVE ASSESSMENT PACKAGES IN PATIENTS WITH SCHIZOPHRENIA AND HEALTHY VOLUNTEERS: TIME EFFECTS ON NEUROPSYCHOLOGICAL PERFORMANCE AND ITS RELATION TO FUNCTIONAL OUTCOME
| العنوان: | F133. A LONGITUDINAL COMPARISON OF TWO NEUROCOGNITIVE ASSESSMENT PACKAGES IN PATIENTS WITH SCHIZOPHRENIA AND HEALTHY VOLUNTEERS: TIME EFFECTS ON NEUROPSYCHOLOGICAL PERFORMANCE AND ITS RELATION TO FUNCTIONAL OUTCOME |
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| المؤلفون: | Elisa Rodríguez-Toscano, Richard Drake, Marta Rapado-Castro, Shôn Lewis, Celso Arango, María José Mayoral, Jane Lees, Gonzalo López |
| المصدر: | Schizophrenia Bulletin. 45:S304-S305 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Poster Session II, business.industry, Neuropsychology, medicine.disease, Outcome (game theory), Psychiatry and Mental health, Text mining, Schizophrenia, Healthy volunteers, Medicine, In patient, business, Neurocognitive, Clinical psychology |
| الوصف: | BACKGROUND: Cognitive impairment is a major unmet need in the treatment of schizophrenia. Over the last decade, the MATRICS Consensus Cognitive Battery (MCCB) and the cognitive-neuroscience-based Cambridge Neuropsychological Test Automated Battery (CANTAB) have been used to assess the effects of novel treatments for cognitive impairment in schizophrenia. Although both batteries purport to assess cognitive function in psychosis (Lees et al., 2017a, Keefe et al., 2013), no previous study has attempted to examine their validity longitudinally and the potential overlap between the two batteries over time. The aim of the current study was to assess the relationship between the MCCB and the CANTAB in the longitudinal assessment of cognitive impairment in schizophrenia. Also, it was targeted to examine the predictive effect of each battery on the psychosocial functioning of subjects. METHODS: A sample of 39 stable schizophrenia outpatients (mean age= 35.79, SD=10.06; males=27, 69.2 %) and 18 controls (mean age=35.94, SD=8.14; males= 12, 66.7 %). completed the MCCB and the CANTAB battery at baseline, and at 2, 4 and 8-weeks follow-up. UCSD Performance-Based Skills Assessment- brief version (UPSA-B), including total score, financial skills and communication skills indices, and Work and Social Assessment Scale (WSAS) scale were administered at baseline to examine psychosocial functioning. Mixed-model repeated measures approach was used for the timepoints mean comparison of each battery independently and the time*battery interaction (including the subjects ID as random variable). Backwards-stepwise linear regressions were performed to determine the best set of cognitive tests/domains derived from the MCCB and/or the CANTAB that would explain the maximum variance for functional outcomes. All the analysis controlled for age including it as covariable. RESULTS: The present study detects practice effects from baseline to follow-up assessments in the CANTAB cognitive battery in visual memory (F3,146= 4.37, p=0.006), reasoning and problem-solving (F3,147= 4.58, p=0.004) and social cognition (F3,239= 2.96, p= 0.033) in patients, and social cognition in controls (F3,66= 10.92, p |
| تدمد: | 1745-1701 0586-7614 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b86166a221ce61ed4d78a7c3b01852b https://doi.org/10.1093/schbul/sbz018.545 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7b86166a221ce61ed4d78a7c3b01852b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17451701 05867614 |
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