Prognostic model for predicting survival in very preterm infants: an external validation study
| العنوان: | Prognostic model for predicting survival in very preterm infants: an external validation study |
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| المؤلفون: | Beek, P.E. van, Groenendaal, F., Onland, W., Koole, S., Dijk, P.H., Dijkman, K.P., Dungen, F. van den, Heijst, A. van, Kornelisse, R.F., Schuerman, F., Westering-Kroon, E. van, Witlox, R.S.G.M., Andriessen, P., Schuit, E., EPI-DAF Study Grp |
| المساهمون: | Pediatrics, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Neonatology, Eindhoven MedTech Innovation Center, Signal Processing Systems, School of Med. Physics and Eng. Eindhoven, EngD School AP, RS: GROW - R4 - Reproductive and Perinatal Medicine, Kindergeneeskunde, MUMC+: MA Medische Staf Kindergeneeskunde (9) |
| المصدر: | BJOG: An International Journal of Obstetrics and Gynaecology, 129(4), 529-538. Wiley-Blackwell Publishing Ltd BJOG: An International Journal of Obstetrics and Gynaecology. Wiley Online Library BJOG: An International Journal of Obstetrics and Gynaecology, 129(4), 529-538. WILEY BJOG: An International Journal of Obstetrics and Gynaecology. Wiley-Blackwell BJOG : An International Journal of Obstetrics and Gynaecology, 129(4), 529-538. Wiley-Blackwell EPI-DAF study group 2021, ' Prognostic model for predicting survival in very preterm infants : an external validation study ', BJOG: An International Journal of Obstetrics and Gynaecology . https://doi.org/10.1111/1471-0528.17010 Bjog-an International Journal of Obstetrics and Gynaecology, 129(4), 529-538. Wiley BJOG-an International Journal Of Obstetrics And Gynaecology, 129(4), 529-538. Wiley |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Male, Pediatrics, medicine.medical_specialty, Neonatal intensive care unit, Calibration (statistics), BIRTH, Population, APPLICABILITY, Cohort Studies, External validity, Intensive Care Units, Neonatal, Infant Mortality, Humans, Infant, Very Low Birth Weight, Medicine, TOOL, very preterm infants, Registries, education, Statistic, Netherlands, RISK, CALIBRATION, education.field_of_study, Models, Statistical, Cesarean Section, business.industry, Singleton, Infant, Newborn, Infant, Obstetrics and Gynecology, Gestational age, mortality, PROBAST, External validation, prediction model, BIAS, Infant, Extremely Premature, Cohort, Female, business |
| الوصف: | Objective: To perform a temporal and geographical validation of a prognostic model, considered of highest methodological quality in a recently published systematic review, for predicting survival in very preterm infants admitted to the neonatal intensive care unit. The original model was developed in the UK and included gestational age, birthweight and gender. Design: External validation study in a population-based cohort. Setting: Dutch neonatal wards. Population or sample: All admitted white, singleton infants born between 23+0 and 32+6 weeks of gestation between 1 January 2015 and 31 December 2019. Additionally, the model’s performance was assessed in four populations of admitted infants born between 24+0 and 31+6 weeks of gestation: white singletons, non-white singletons, all singletons and all multiples. Methods: The original model was applied in all five validation sets. Model performance was assessed in terms of calibration and discrimination and, if indicated, it was updated. Main outcome measures: Calibration (calibration-in-the-large and calibration slope) and discrimination (c statistic). Results: Out of 6092 infants, 5659 (92.9%) survived. The model showed good external validity as indicated by good discrimination (c statistic 0.82, 95% CI 0.79–0.84) and calibration (calibration-in-the-large 0.003, calibration slope 0.92, 95% CI 0.84–1.00). The model also showed good external validity in the other singleton populations, but required a small intercept update in the multiples population. Conclusions: A high-quality prognostic model predicting survival in very preterm infants had good external validity in an independent, nationwide cohort. The accurate performance of the model indicates that after impact assessment, implementation of the model in clinical practice in the neonatal intensive care unit could be considered. Tweetable abstract: A high-quality model predicting survival in very preterm infants is externally valid in an independent cohort. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1470-0328 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b8fb574bf76f63531c28c612c062bc0 https://pure.eur.nl/en/publications/093a12f1-30ed-48de-b9d0-777959be80c3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7b8fb574bf76f63531c28c612c062bc0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14700328 |
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