201Tl-SPECT in low-grade gliomas: diagnostic accuracy in differential diagnosis between tumour recurrence and radionecrosis
| العنوان: | 201Tl-SPECT in low-grade gliomas: diagnostic accuracy in differential diagnosis between tumour recurrence and radionecrosis |
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| المؤلفون: | Manuel Gómez-Río, Antonio Rodríguez-Fernández, Simeón Ortega Lozano, Carlos Ramos Font, Escarlata López Ramírez, Jose M. Llamas-Elvira, Majed Katati, Dolores Martínez del Valle Torres |
| المصدر: | European Journal of Nuclear Medicine and Molecular Imaging. 31 |
| بيانات النشر: | Springer Science and Business Media LLC, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Validation study, 201tl spect, Treatment outcome, Diagnostic accuracy, Sensitivity and Specificity, Severity of Illness Index, Diagnosis, Differential, Necrosis, Neoplasm Recurrence, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Thallium, Radiation Injuries, Tomography, Emission-Computed, Single-Photon, medicine.diagnostic_test, Brain Neoplasms, business.industry, Brain, Reproducibility of Results, Glioma, General Medicine, Prognosis, Tumor recurrence, Treatment Outcome, Female, Radiology, Neoplasm Recurrence, Local, Radiopharmaceuticals, Differential diagnosis, business, Nuclear medicine, Emission computed tomography |
| الوصف: | The aim of this work was to describe the usefulness of a simple (201)Tl single-photon emission computed tomography (SPECT) technique in the differential diagnosis between tumour recurrence and radionecrosis during the follow-up of patients treated for low-grade gliomas.The study population comprised 84 patients treated for low-grade gliomas who showed suspicion of tumour recurrence during their follow-up. All patients were examined by neuro-anatomical imaging procedures (CT, MRI) and (201)Tl-SPECT. (201)Tl-SPECT images were assessed by visual analysis based only on the information on the prescription form and by estimation of the uptake index (ratio of mean counts in the lesion to those in the contralateral mirror area). Examiners were blinded to the results of other tests.Under these conditions, the neuro-anatomical procedures yielded 26.2% inconclusive reports, with a global diagnostic accuracy of 0.61, a sensitivity of 0.63 and a specificity of 0.59. The global diagnostic accuracy for (201)Tl-SPECT was 0.83, with a sensitivity of 0.88 and a specificity of 0.76. Diagnostic pitfalls were observed in regions with physiological (201)Tl uptake, i.e. the posterior cranial fossa, diencephalon, lateral ventricles and cavernous and longitudinal venous sinuses. An uptake index cut-off value of 1.25 showed a sensitivity of 0.90 and specificity of 0.80 for detection of tumour activity.(201)Tl-SPECT has adequate diagnostic accuracy to be part of routine algorithms in the follow-up of patients with low-grade glioma suspected of tumour recurrence, as an alternative to neuro-anatomical procedures and not solely as a complementary test. |
| تدمد: | 1619-7089 1619-7070 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c05a7b39ab70fee696c38ec05f237a2 https://doi.org/10.1007/s00259-004-1501-5 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7c05a7b39ab70fee696c38ec05f237a2 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 16197089 16197070 |
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