التفاصيل البيبلوغرافية
العنوان:
Discovery and Optimization of a Synthetic Class of Nectin-4-Targeted CD137 Agonists for Immuno-oncology
المؤلفون:
Punit Upadhyaya , Julia Kristensson , Johanna Lahdenranta , Elizabeth Repash , Jun Ma , Jessica Kublin , Gemma E. Mudd , Lia Luus , Phil Jeffrey , Kristen Hurov , Kevin McDonnell , Nicholas Keen
المصدر:
Journal of medicinal chemistry . 65(14)
سنة النشر:
2022
مصطلحات موضوعية:
Mice , Tumor Necrosis Factor Receptor Superfamily, Member 9 , Neoplasms , Drug Discovery , Nectins , Molecular Medicine , Animals , Cell Adhesion Molecules
الوصف:
CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based linkers, synthetic bicyclic peptides targeting CD137 were conjugated to
تدمد:
1520-4804
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27610ba02170186a7dd0cfd287a4aa https://pubmed.ncbi.nlm.nih.gov/35819182
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....7c27610ba02170186a7dd0cfd287a4aa
قاعدة البيانات:
OpenAIRE
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