Intralesional combined digoxin and furosemide in plantar warts: Does it work?
| العنوان: | Intralesional combined digoxin and furosemide in plantar warts: Does it work? |
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| المؤلفون: | Ahmed Abdelfattah Afify, Wessam Moustafa Abo-Elmagd, Ghada Fathy |
| المصدر: | Journal of Cosmetic Dermatology. 20:2606-2611 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Digoxin, medicine.medical_specialty, medicine.medical_treatment, Urology, Dermatology, Injections, Intralesional, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Plantar warts, Furosemide, law, medicine, Humans, Effective treatment, Saline, business.industry, Significant difference, virus diseases, medicine.disease, Response to treatment, Treatment Outcome, 030220 oncology & carcinogenesis, Warts, business, medicine.drug |
| الوصف: | Background Warts are small, benign growths caused by human papilloma virus. No treatment has yet proven 100% effective for a cure. DNA viruses rely on K + influx for replication. Both digoxin and furosemide inhibit the K + influx by interacting with cell membrane ion co-transporters. Therefore, it is hypothesized that these two compounds may be valuable in the treatment of warts. Aims Our aim was to evaluate the efficacy and safety of intralesional injection of a combination of digoxin and furosemide in treatment of plantar warts. Patients/methods This two-armed single blinded randomized clinical trial included 40 cases with multiple plantar warts (≥3warts) divided into 2 groups (20 cases each). The first group received intralesional normal saline and the second group received intralesional combined digoxin and furosemide, one session every week for maximum 5 injection sessions. Results On comparing between the 2 groups regarding response to treatment (reduction in number of warts), the first group showed no change in number of warts (82 warts before and after treatment), whereas, in the second group, the number of warts before treatment was 80 while after treatment it was 40 (50% reduction in number). There was a statistically significant difference between the two groups as regard the change in the total number of warts (P Conclusions Intralesional injection of combined digoxin and furosemide is safe and effective treatment option in multiple plantar warts. |
| تدمد: | 1473-2165 1473-2130 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2773864960920fab8a0d15eb68c166 https://doi.org/10.1111/jocd.13913 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7c2773864960920fab8a0d15eb68c166 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732165 14732130 |
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