Prognostic Impact of Breast-Conserving Therapy Versus Mastectomy of BRCA1/2 Mutation Carriers Compared With Noncarriers in a Consecutive Series of Young Breast Cancer Patients
| العنوان: | Prognostic Impact of Breast-Conserving Therapy Versus Mastectomy of BRCA1/2 Mutation Carriers Compared With Noncarriers in a Consecutive Series of Young Breast Cancer Patients |
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| المؤلفون: | Adri C. Voogd, Vincent T.H.B.M. Smit, Jan J. Jobsen, Pieter J. Westenend, Marjanka K. Schmidt, Hester S. A. Oldenburg, Sabine Siesling, Linetta B. Koppert, Flora E. van Leeuwen, Laura J. van't Veer, Rob A. E. M. Tollenaar, Nicola S. Russell, Emiel J. Th. Rutgers, Alexandra J. van den Broek |
| المساهمون: | Surgery, Health Technology & Services Research, Epidemiologie, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, RS: CAPHRI - R5 - Optimising Patient Care |
| المصدر: | Annals of Surgery, 270(2), 364-372. LIPPINCOTT WILLIAMS & WILKINS Annals of Surgery, 270(2), 364-372. Lippincott Williams & Wilkins Annals of Surgery, 270(2), 364-372. Lippincot, Williams & Wilkins Annals of Surgery |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Oncology, medicine.medical_treatment, DNA Mutational Analysis, Mastectomy, Segmental, law.invention, Brca1 2 mutation, 0302 clinical medicine, Randomized controlled trial, law, skin and connective tissue diseases, Netherlands, RISK, education.field_of_study, BRCA1 Protein, WOMEN, mastectomy, DNA, Neoplasm, Middle Aged, Prognosis, 10-YEAR, Survival Rate, 030220 oncology & carcinogenesis, Cohort, Mutation (genetic algorithm), breast-conserving therapy, 030211 gastroenterology & hepatology, Female, Mastectomy, Radical, Mastectomy, RADIOTHERAPY, Adult, medicine.medical_specialty, Heterozygote, CONSERVATION, Population, Breast Neoplasms, survival, 03 medical and health sciences, Breast cancer, breast cancer, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Humans, education, BRCA2 Protein, business.industry, 20-YEAR FOLLOW-UP, medicine.disease, BRCA1, 22/4 OA procedure, BRCA2, Radiation therapy, TUMOR RECURRENCE, Mutation, RADIATION, Surgery, business |
| الوصف: | Objective: To investigate the effects of different types of surgery on breast cancer prognosis in germline BRCA1/BRCA2 mutation carriers compared with noncarriers.Summary of Background Data: Although breast-conserving therapy (breast-conserving surgery followed by radiotherapy) has been associated with more local recurrences than mastectomy, no differences in overall survival have been found in randomized trials performed in the general breast cancer population. Whether breast-conservation can be safely offered to BRCA1/2 mutation carriers is debatable.Methods: The study comprised a cohort of women with invasive breast cancer diagnosed |
| وصف الملف: | application/pdf |
| تدمد: | 1528-1140 0003-4932 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c46239a439cc917e5a0af2014cd8b13 https://pubmed.ncbi.nlm.nih.gov/29727326 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7c46239a439cc917e5a0af2014cd8b13 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15281140 00034932 |
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