أعرض في EDS

HLA-G 14 bp insertion/deletion polymorphism and its association with sHLA-G levels in Behçet’s disease Tunisian patients

التفاصيل البيبلوغرافية
العنوان: HLA-G 14 bp insertion/deletion polymorphism and its association with sHLA-G levels in Behçet’s disease Tunisian patients
المؤلفون: Wahiba Sakly, S. Hammami, S. Feki, O. Harzallah, K. Sakly, Ibtissem Ghedira, Massoud Mirshahi, N. Sakly, M. Maatouk
المصدر: Human Immunology. 77:90-95
بيانات النشر: Elsevier BV, 2016.
سنة النشر: 2016
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Tunisia, Adolescent, Genotype, DNA Mutational Analysis, Immunology, Human leukocyte antigen, Behcet's disease, Gastroenterology, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, law, HLA-G, Internal medicine, Active disease, medicine, Humans, Immunology and Allergy, Insertion deletion, Genetic Predisposition to Disease, Allele, Child, 3' Untranslated Regions, Genetic Association Studies, Polymerase chain reaction, HLA-G Antigens, Polymorphism, Genetic, business.industry, Behcet Syndrome, General Medicine, Plasma levels, Middle Aged, medicine.disease, Mutagenesis, Insertional, 030104 developmental biology, Disease Progression, Female, business, 030215 immunology
الوصف: The purpose of this study was to investigate the HLA-G 3'UTR 14 bp polymorphism and sHLA-G levels in Tunisian patients with BD. The study included 119 patients with BD and 170 healthy blood donors (HD). HLA-G 14 bp polymorphism was genotyped by polymerase chain reaction. Serum levels of soluble HLA-G (sHLA-G) were measured using a commercial ELISA kit. A significant increased frequency of the -14 bp HLA-G allele was detected in patients with BD compared to HD (0.58 vs 0.49, p=0.023), and a significant increased frequency of HLA-G -14/-14 bp was observed in patients with BD compared to HD [0.37 vs 0.22, p=0.007, OR 2.04 (95% CI 1.21-3.42)]. The mean plasmatic concentration of sHLA-G levels were significantly increased in patients with active disease [231.63±286.4 U/mL] compared to those with inactive disease (103.14±77.8 U/mL, p=0.03) and HD (121.41±24.1 U/mL, p=0.04). Furthermore, our results showed that there is no association between HLA-G 14 bp polymorphism and sHLA-G plasma levels.
تدمد: 0198-8859
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c4955c6716c2ffa712cfe6297b99d0a
https://doi.org/10.1016/j.humimm.2015.10.016
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....7c4955c6716c2ffa712cfe6297b99d0a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:01988859