Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure
| العنوان: | Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure |
|---|---|
| المؤلفون: | Lars Køber, Jensen G, Per Hildebrandt, Axel Brandes, Christian Torp-Pedersen, Christian Hassager, Hans Eiskjær, Jesper Hastrup Svendsen, Finn Gustafsson, Regitze Videbæk, Lars Videbæk, Jens Nielsen, Flemming Hald Steffensen, Jens Jakob Thune, Dan Eik Høfsten, Eva Korup, Anna Margrethe Thøgersen, Kenneth Egstrup, Jens Haarbo, S. Pehrson, Niels Eske Bruun |
| المصدر: | Køber, L, Thune, J J, Nielsen, J C, Haarbo, J, Videbæk, L, Korup, E, Jensen, G, Hildebrandt, P, Steffensen, F H, Bruun, N E, Eiskjær, H, Brandes, A, Thøgersen, A M, Gustafsson, F, Egstrup, K, Videbæk, R, Hassager, C, Svendsen, J H, Høfsten, D E, Torp-Pedersen, C, Pehrson, S & DANISH Investigators 2016, ' Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure ', The New England Journal of Medicine, vol. 375, no. 13, pp. 1221-1230 . https://doi.org/10.1056/NEJMoa1608029 Køber, L, Thune, J J, Nielsen, J C, Haarbo, J, Videbæk, L, Korup, E, Jensen, G, Hildebrandt, P, Hald Steffensen, F, Bruun, N E, Eiskjær, H, Brandes, A, Thøgersen, A M, Gustafsson, F, Egstrup, K, Videbæk, R, Hassager, C, Svendsen, J H, Høfsten, D E, Torp-Pedersen, C, Pehrson, S & DANISH Investigators 2016, ' Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure ', The New England Journal of Medicine, vol. 375, no. 13, pp. 1221-1230 . https://doi.org/10.1056/NEJMoa1608029 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Management of heart failure, Cardiac resynchronization therapy, 030204 cardiovascular system & hematology, Sudden cardiac death, CARDIOVERTER-DEFIBRILLATOR, Coronary artery disease, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Journal Article, Humans, 030212 general & internal medicine, Mortality, Aged, RISK, CARDIAC-RESYNCHRONIZATION THERAPY, Ejection fraction, medicine.diagnostic_test, business.industry, MORTALITY, Cardiac Pacing, Artificial, DEATH, Stroke Volume, General Medicine, Stroke volume, Middle Aged, medicine.disease, DILATED CARDIOMYOPATHY, PREVENTION, Defibrillators, Implantable, AMIODARONE, Death, Sudden, Cardiac, Cardiovascular Diseases, Heart failure, Cardiology, Female, TRIAL, business, Follow-Up Studies, Heart Failure, Systolic |
| الوصف: | Background The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). Methods In a randomized, controlled trial, 556 patients with symptomatic systolic heart failure (left ventricular ejection fraction, ≤35%) not caused by coronary artery disease were assigned to receive an ICD, and 560 patients were assigned to receive usual clinical care (control group). In both groups, 58% of the patients received CRT. The primary outcome of the trial was death from any cause. The secondary outcomes were sudden cardiac death and cardiovascular death. Results After a median follow-up period of 67.6 months, the primary outcome had occurred in 120 patients (21.6%) in the ICD group and in 131 patients (23.4%) in the control group (hazard ratio, 0.87; 95% confidence interval [CI], 0.68 to 1.12; P=0.28). Sudden cardiac death occurred in 24 patients (4.3%) in the ICD group and in 46 patients (8.2%) in the control group (hazard ratio, 0.50; 95% CI, 0.31 to 0.82; P=0.005). Device infection occurred in 27 patients (4.9%) in the ICD group and in 20 patients (3.6%) in the control group (P=0.29). Conclusions In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care. (Funded by Medtronic and others; DANISH ClinicalTrials.gov number, NCT00542945 .). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6346ebe47bbd0a0dff17db9e9201ff https://pure.au.dk/portal/da/publications/defibrillator-implantation-in-patients-with-nonischemic-systolic-heart-failure(9273479b-57f2-4bc6-9e42-5bc30f6726e7).html |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7c6346ebe47bbd0a0dff17db9e9201ff |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |