A Role for Spectrin in Dynactin-dependent Melanosome Transport in Xenopus laevis Melanophores
| العنوان: | A Role for Spectrin in Dynactin-dependent Melanosome Transport in Xenopus laevis Melanophores |
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| المؤلفون: | Sara Aspengren, Margareta Wallin |
| المصدر: | Pigment Cell Research. 17:295-301 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Clinical Biochemistry, Dynein, Melanophores, macromolecular substances, Plant Science, Biology, Motor protein, Xenopus laevis, Microtubule, Animals, Immunoprecipitation, Tissue Distribution, Spectrin, ACTR1A, Melanosome, Melanosomes, Biological Transport, Dynactin Complex, Cell Biology, Cell biology, Melanosome transport, Dynactin, Microtubule-Associated Proteins, Agronomy and Crop Science, Developmental Biology |
| الوصف: | The bi-directional movement of pigment granules in frog melanophores involves the microtubule-based motors cytoplasmic dynein, which is responsible for aggregation, and kinesin II and myosin V, which are required for dispersion of pigment. It was recently shown that dynactin acts as a link between dynein and kinesin II and melanosomes, but it is not fully understood how this is regulated and if more proteins are involved. Here, we suggest that spectrin, which is known to be associated with Golgi vesicles as well as synaptic vesicles in a number of cells, is of importance for melanosome movements in Xenopus laevis melanophores. Large amounts of spectrin were found on melanosomes isolated from both aggregated and dispersed melanophores. Spectrin and two components of the oligomeric dynactin complex, p150 g l u e d and Arpl/centractin, co-localized with melanosomes during aggregation and dispersion, and the proteins were found to interact as determined by co-immunoprecipitation. Spectrin has been suggested as an important link between cargoes and motor proteins in other cell types, and our new data indicate that spectrin has a role in the specialized melanosome transport processes in frog melanophores, in addition to a more general vesicle transport. |
| تدمد: | 1600-0749 0893-5785 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c75bd65a49c4eb0a4c3100187e72f5a https://doi.org/10.1111/j.1600-0749.2004.00150.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7c75bd65a49c4eb0a4c3100187e72f5a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000749 08935785 |
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