التفاصيل البيبلوغرافية
العنوان:
Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists
المؤلفون:
Marc L. Reitman , Cheng Guo , Theresa M. Kelly , Constantin Tamvakopoulos , Joseph M. Metzger , Tianying Jian , Howard Y. Chen , Arthur A. Patchett , Oksana C. Palyha , Alison M. Strack , Allan J. Goodman , Ravi P. Nargund , Peter H. Dobbelaar , Yanqing Kan , Mark Hadden , Larry Yet , Peter R. Guzzo , Qianping Peng , Linus S. Lin , Shuwen He , Lauren P. Shearman , Alan J. Henderson , Carina P. Tan , Sargent Bruce J , Xiao-Ming Guan , Scott D. Feighner , Iyassu K. Sebhat , Jie Pan , Jian Liu , Donald J. Marsh , Matthew J. Wyvratt , Andrew D. Howard , Megan Ruenz
المصدر:
Bioorganic & Medicinal Chemistry Letters . 20:1913-1917
بيانات النشر:
Elsevier BV, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
Agonist , medicine.drug_class , Clinical Biochemistry , Biological Availability , Pharmaceutical Science , Pharmacology , Biochemistry , Structure-Activity Relationship , chemistry.chemical_compound , Drug Discovery , medicine , Animals , Humans , Potency , Structure–activity relationship , Molecular Biology , Biphenyl , Chemistry , Drug discovery , fungi , Organic Chemistry , Imidazoles , Rats , Bombesin receptor , Bioavailability , Receptors, Bombesin , Molecular Medicine , Bombesin Receptor Subtype-3
الوصف:
We report SAR studies on a novel non-peptidic bombesin receptor subtype-3 (BRS-3) agonist lead series derived from high-throughput screening hit RY-337. This effort led to the discovery of compound 22e with significantly improved potency at both rodent and human BRS-3.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9388422b542c24893358d41aa77156 https://doi.org/10.1016/j.bmcl.2010.01.154
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....7c9388422b542c24893358d41aa77156
قاعدة البيانات:
OpenAIRE
