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Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis

التفاصيل البيبلوغرافية
العنوان: Detection of Mycobacterium tuberculosis in urine by Xpert MTB/RIF Ultra: A useful adjunctive diagnostic tool in HIV-associated tuberculosis
المؤلفون: David B. Meya, Gerald Mugumya, Jayne Ellis, Fiona V Cresswell, David R. Boulware, Vincent Wadda, Rachel R. Atherton, Caleb P Skipper, Kiiza Kandole Tadeo
المصدر: International Journal of Infectious Diseases
International Journal of Infectious Diseases, Vol 75, Iss, Pp 92-94 (2018)
بيانات النشر: Elsevier, 2018.
سنة النشر: 2018
مصطلحات موضوعية: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Tuberculosis, 030106 microbiology, Human immunodeficiency virus (HIV), HIV Infections, Disseminated tb, Diagnostic accuracy, Urine, medicine.disease_cause, Sensitivity and Specificity, Article, World health, lcsh:Infectious and parasitic diseases, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, Xpert MTB/RIF Ultra, Internal medicine, medicine, Humans, lcsh:RC109-216, Uganda, 030212 general & internal medicine, Tuberculosis, Pulmonary, biology, business.industry, Extrapulmonary tuberculosis, Renal tuberculosis, technology, industry, and agriculture, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, 3. Good health, Infectious Diseases, Female, business, Nucleic Acid Amplification Techniques
الوصف: Highlights • Ultra has detected Mycobacterium tuberculosis in the urine of a patient with renal TB. • Use of Xpert or Ultra on urine is not currently recommended due to lack of evidence. • Urine Ultra may be useful in the diagnosis of extra-pulmonary TB in persons with HIV. • Further study is required to characterise the diagnostic accuracy of urine Ultra.
In January 2017, the World Health Organisation recommended the Xpert® MTB/RIF Ultra assay (Ultra) for tuberculosis (TB) diagnosis. Ultra offers improved analytical sensitivity when compared with the initial Xpert® MTB/RIF (Xpert) assay for the detection of Mycobacterium tuberculosis. Ultra is therefore likely to be of particular benefit for detecting paucibacillary TB. We present a case from Uganda demonstrating Ultra positivity in urine from an HIV-infected patient presenting with altered mental status and urinary incontinence, and no other signs of active pulmonary or extrapulmonary TB. This represents the first published instance of a diagnosis of extrapulmonary TB made on the basis of a positive urine Ultra assay. The use of Ultra on urine may be a useful addition to the diagnostic armamentarium for disseminated TB in persons with HIV co-infection. The diagnostic accuracy of urine Ultra should be characterised further via prospective studies.
وصف الملف: application/pdf
اللغة: English
تدمد: 1201-9712
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd0b0a40b1bcd9abad5500abdedb409
https://researchonline.lshtm.ac.uk/id/eprint/4648629/1/Detection-of-Mycobacterium-tuberculosis-in-urine-by-Xpert-MTB-RIF-Ultra.pdf
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....7cd0b0a40b1bcd9abad5500abdedb409
قاعدة البيانات: OpenAIRE
الوصف
تدمد:12019712