Real-life outcomes of teriflunomide treatment in patients with relapsing multiple sclerosis: TAURUS-MS observational study
| العنوان: | Real-life outcomes of teriflunomide treatment in patients with relapsing multiple sclerosis: TAURUS-MS observational study |
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| المؤلفون: | Jennifer S Kullmann, Andrew Chan, Ulrich Engelmann, Klaus Tiel-Wilck, Boris A. Kallmann |
| المصدر: | Kallmann, Boris A; Tiel-Wilck, Klaus; Kullmann, Jennifer S; Engelmann, Ulrich; Chan, Andrew (2019). Real-life outcomes of teriflunomide treatment in patients with relapsing multiple sclerosis: TAURUS-MS observational study. Therapeutic advances in neurological disorders, 12, p. 1756286419835077. Sage 10.1177/1756286419835077 <http://dx.doi.org/10.1177/1756286419835077> Therapeutic Advances in Neurological Disorders, Vol 12 (2019) Therapeutic Advances in Neurological Disorders |
| بيانات النشر: | Sage, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, patient-related outcomes, 610 Medicine & health, multiple sclerosis, lcsh:RC346-429, 03 medical and health sciences, chemistry.chemical_compound, oral, 0302 clinical medicine, Internal medicine, Teriflunomide, Medicine, In patient, 030212 general & internal medicine, Immunomodulatory Agent, observational, lcsh:Neurology. Diseases of the nervous system, Original Research, Pharmacology, treatment, business.industry, Multiple sclerosis, medicine.disease, Neurology, chemistry, Observational study, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Background: Teriflunomide is a once-daily oral immunomodulatory agent approved for the treatment of relapsing–remitting multiple sclerosis (MS). We aimed to obtain data on the effectiveness, tolerability, and subject satisfaction with teriflunomide (Aubagio®) under clinical practice conditions in unselected MS patients. Methods: This work was a non-interventional, prospective, longitudinal, observational study in 307 sites in Germany. Results: A total of 1128 patients were eligible for the efficacy analysis [67.5% female; mean age (± standard deviation) 44.9 ± 9.7 years, range 20–73 years]. Time since first MS symptoms was 10.6 ± 8.2 years, and time since MS diagnosis was 8.9 ± 7.6 years. Expanded Disability Status Scale (EDSS) score at inclusion was 2.3 ± 1.5 (70.4% with score < 3.5). The mean observation period was 16.3 ± 9.1 months. A total of 75.2% had received previous disease-modifying therapies (DMTs) at any time. Of these patients, 504 (44.7%) received no DMT within 6 months of study entry, 593 patients (52.6%) had DMT discontinued prior to study entry [glatiramer acetate in 10.6%, subcutaneous interferon-beta 1a (IFNβ-1a) in 9.3%, intramuscular IFNβ-1a or IFNβ-1b in 6.6% each, azathioprine oral in 0.4%, other in 7.3%, last medication not known in 12.0%]. The mean annualized relapse rate decreased from 0.87 in the 24 months prior to study entry to 0.35 in the 24 months after study entry ( n = 468; p ⩽ 0.001). EDSS and Fatigue Severity Scale remained stable. In patients who received previous MS treatments, Treatment Satisfaction Questionnaire (TSQM-9) values (maximum = 100), for the observation at 24 months improved by 8.1 points for effectiveness, 17.0 points for convenience, and 15.3 points for global satisfaction ( p ⩽ 0.001 each, compared with study entry). In the safety cohort ( n = 1139), the proportion of patients with adverse events (AEs) of any severity was 35.8%, and with serious events 13.0%. The most frequently reported AEs were diarrhea ( n = 55), followed by MS relapse ( n = 48), hair thinning ( n = 38), and viral upper respiratory tract infection ( n = 31). Conclusions: Relapse rate was halved during the observation period in comparison with the same time period before study entry. Patient satisfaction with teriflunomide was high in this real-world observation of patients, the majority of whom switched from other DMTs. The safety and tolerability profile of teriflunomide was similar to that reported in previous clinical trials. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d01af5e2a83cbf36fd8e732d9c562c8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d01af5e2a83cbf36fd8e732d9c562c8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |