Resolvin D2 attenuates chronic pain–induced depression‐like behavior in mice
| العنوان: | Resolvin D2 attenuates chronic pain–induced depression‐like behavior in mice |
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| المؤلفون: | Natsuko Hitora-Imamura, Masabumi Minami, Satoshi Deyama, Hiroe Suzuki |
| المصدر: | Neuropsychopharmacology Reports |
| بيانات النشر: | John Wiley and Sons Inc., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Docosahexaenoic Acids, Micro Reports, Pharmacology, Micro Report, chemistry.chemical_compound, Mice, medicine, Animals, Pharmacology (medical), pain, n‐3 polyunsaturated fatty acid, Depression (differential diagnoses), resolvin, antidepressant, business.industry, Depression, Chronic pain, Nerve injury, medicine.disease, Tail suspension test, Antidepressive Agents, Psychiatry and Mental health, Clinical Psychology, chemistry, Docosahexaenoic acid, Neuropathic pain, Antidepressant, medicine.symptom, Chronic Pain, business, Resolvin |
| الوصف: | Aim We previously demonstrated that intracerebroventricular injection of resolvin D2 (RvD2), a bioactive lipid mediator derived from docosahexaenoic acid, ameliorated depression‐like behavior in lipopolysaccharide‐induced and chronic mild stress–induced mouse models of depression. In the present study, we examined the antidepressant effect of RvD2 on chronic pain–induced depression‐like behavior. Methods To prepare the neuropathic pain model, mice were subjected to surgery for unilateral spared nerve injury. Two weeks after surgery, the antidepressant effect of RvD2 was examined using the tail suspension test. Results Chronic pain significantly increased immobility time, and this depression‐like behavior was attenuated by intracerebroventricular injection of RvD2 (10 ng). No effect of RvD2 on the locomotor activity was observed. Conclusion RvD2 produces an antidepressant effect in a murine model of chronic pain–induced depression and may be a promising lead for the development of novel antidepressants. Comorbidity of chronic pain and depression has long been recognized in the clinic. Therefore, in the present study, we examined the antidepressant effect of resolvin D2, a bioactive lipid mediator derived from docosahexaenoic acid, on chronic pain–induced depression‐like behavior. Resolvin D2 produced an antidepressant effect in a murine model of chronic pain–induced depression and may be a promising lead for the development of novel antidepressants. |
| اللغة: | English |
| تدمد: | 2574-173X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1377f8ffbb734713cc1e1af3acba48 http://europepmc.org/articles/PMC8411310 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d1377f8ffbb734713cc1e1af3acba48 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2574173X |
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