Urine NGAL and KIM-1: tubular injury markers in acute lymphoblastic leukemia survivors
| العنوان: | Urine NGAL and KIM-1: tubular injury markers in acute lymphoblastic leukemia survivors |
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| المؤلفون: | Maryna Krawczuk-Rybak, Katarzyna Taranta-Janusz, Katarzyna Konończuk, Anna Wasilewska, Edyta Szymczak, Katarzyna Muszyńska-Rosłan, Eryk Latoch |
| المصدر: | Cancer Chemotherapy and Pharmacology |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Cancer Research, 030232 urology & nephrology, Urine, Acute lymphoblastic leukemia, Toxicology, Gastroenterology, Childhood cancer survivors, chemistry.chemical_compound, 0302 clinical medicine, Cancer Survivors, Medicine, Pharmacology (medical), Hepatitis A Virus Cellular Receptor 1, Child, Cumulative dose, Acute kidney injury, Acute Kidney Injury, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Total body irradiation, Urine KIM-1, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Original Article, Female, Chronic kidney diseases, medicine.medical_specialty, Adolescent, Urinary system, Antineoplastic Agents, Urine NGAL, Nephrotoxicity, Young Adult, 03 medical and health sciences, Lipocalin-2, Internal medicine, Humans, Renal Insufficiency, Chronic, Pharmacology, Creatinine, business.industry, Infant, medicine.disease, CCS, chemistry, Case-Control Studies, business, Biomarkers, Follow-Up Studies, Kidney disease |
| الوصف: | Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used in supportive care may induce acute kidney injury (AKI) or lead to chronic kidney disease (CKD). The aim of this study was to test the hypothesis whether urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) are increased in acute lymphoblastic leukemia (ALL) survivors. Method The study cohort consisted of 86 patients (42 females) previously treated for ALL. The median time after cessation of treatment was 6.55 (IQR: 1.96–9.93) years and median age at the time of study: 12 (IQR: 6.76–16.00). The control group included 53 healthy peers. Immunoenzymatic ELISA commercial kits were used to measure urine KIM-1 and NGAL levels. Results The median levels of urine uNGAL (p p p 2. The NGAL/cr. ratio seemed to be the best predictor of decreased eGFR (AUC = 0.65). The cumulative dose of methotrexate and cyclophosphamide did not predict the values of the urine NGAL, NGAL/cr., KIM-1/cr. and eGFR. Five years after the end of treatment, the patients had higher levels of uKIM-1 (1.02 ± 0.8 vs. 0.62 ± 0.6 ng/mL, p p 2, p Conclusion We demonstrated that ALL survivors have higher levels of urine NGAL, NGAL/cr. and uKIM-1/cr. ratio as compared to the control group. Further long-term follow-up studies are necessary to assess the significance of the NGAL and KIM-1 and their relationship to kidney damage after anticancer treatment in childhood. |
| تدمد: | 1432-0843 0344-5704 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d242b87fe16325e6e4f22a79c70c96b https://doi.org/10.1007/s00280-020-04164-3 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d242b87fe16325e6e4f22a79c70c96b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320843 03445704 |
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