Toxicity of environmental ozone exposure on mice olfactory bulbs, using Western blot technique
| العنوان: | Toxicity of environmental ozone exposure on mice olfactory bulbs, using Western blot technique |
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| المؤلفون: | Samah Abd-Elrahim Batran |
| المصدر: | Toxicology Reports Toxicology Reports, Vol 7, Iss, Pp 453-459 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Health, Toxicology and Mutagenesis, CYP1A1, 010501 environmental sciences, Toxicology, medicine.disease_cause, 01 natural sciences, Green fluorescent protein, 03 medical and health sciences, 0302 clinical medicine, Olfactory bulb, Ozone, Western blot, lcsh:RA1190-1270, medicine, Ozone exposure, 0105 earth and related environmental sciences, lcsh:Toxicology. Poisons, biology, Strain (chemistry), medicine.diagnostic_test, Cytochrome P450, Regular Article, Molecular biology, Toxicity, biology.protein, 030217 neurology & neurosurgery, Oxidative stress, 4HNE |
| الوصف: | Highlights • Ozone (O3) exposure caused an oxidative stress state in the olfactory bulbs (OB) OB of Swiss Webster mice. • Similar However, this effect was not observed in C57BL/6J mouse strain. • The body weight of the all O3 exposed mice was decreased. • The Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) is absent in the C57BL/6J Green fluorescent protein (GFP) O3 exposed mice. Environmental ozone (O3) exposure has adverse effects on different body systems. This experimental work aimed to study the effect(s) of O3 exposure on the olfactory bulbs (OB) of Swiss Webster and C57BL/6J mouse strains, using Western blot technique. Both mice strains were exposed to different O3 doses for different number of exposures and durations. The results indicated that O3 exposure caused a significant increase in the level of the proteins involved in the oxidative stress state such as 4-hydroxynonenal (4HNE) and Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), in addition to the total OB proteins in Swiss Webster mouse strain. However, this effect was not observed in C57BL/6J mouse strain. Furthermore, CYP1A1 was completely absent in the Green fluorescent protein (GFP) C57BL/6J O3 exposed mice. Moreover, O3 exposure caused a significant decrease in the body weight of the tested mice from the two strains. |
| تدمد: | 2214-7500 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4892862d7292955c0b3cde8bccb7c4 https://pubmed.ncbi.nlm.nih.gov/32190549 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d4892862d7292955c0b3cde8bccb7c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22147500 |
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