Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria
| العنوان: | Vescalagin and Castalagin Present Bactericidal Activity toward Methicillin-Resistant Bacteria |
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| المؤلفون: | Ana R. Araújo, Ana Carolina Araújo, Rui L. Reis, Ricardo A. Pires |
| المساهمون: | Universidade do Minho |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP ACS Biomaterials Science & Engineering |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Staphylococcus aureus, 0206 medical engineering, Biomedical Engineering, Microbial Sensitivity Tests, 02 engineering and technology, medicine.disease_cause, Bacterial cell structure, Microbiology, Biomaterials, Methicillin, Methicillin-resistant Staphylococcus epidermidis, chemistry.chemical_compound, Staphylococcus epidermidis, medicine, Castalagin, Science & Technology, Vescalagin, biology, 021001 nanoscience & nanotechnology, biology.organism_classification, Antimicrobial, 020601 biomedical engineering, Hydrolyzable Tannins, 3. Good health, chemistry, Pseudomonas aeruginosa, Methicillin Resistance, Methicillin-resistant Staphylococcus aureus, Cork, 0210 nano-technology, Antibacterial activity, Bacteria |
| الوصف: | "Published online 17 February 2021" Polyphenols have been extensively exploited in the biomedical field because of their wide range of bioactive properties and historical use as traditional medicines. They typically present antioxidant, antimicrobial, antiamyloidogenic, and/or antitumor activities. In particular, cork water extracts and their components, have been previously reported to present antioxidant and antiamyloidogenic properties. On the basis of this knowledge, we tested cork water extract (CWE), cork water enriched extract (CWE-E), vescalagin/castalagin (two of the main polyphenols present in CWE and CWE-E) for their antibacterial activity against four bacterial strains, namely, methicillin-resistant Staphylococcus epidermidis (MRSE), Staphylococcus aureus (SA), methicillin-resistant Staphylococcus aureus (MRSA), and Pseudomonas aeruginosa (PA). Vescalagin and castalagin presented bactericidal activity against all the tested bacterial strains, in particular toward the methicillin-resistant ones, i.e., MRSA and MRSE, as well as the ability to inhibit the formation of biofilms and to disrupt preformed ones. Moreover, vescalagin/castalagin seem to modulate the normal assembly of the peptidoglycans at the bacteria surface, promoting the disruption of their cell wall, leading to bacterial cell death. We also demonstrate that vescalagin/castalagin can be loaded into alginate hydrogels to generate antibacterial biomaterials that are not toxic to eukaryotic cells. We acknowledge the financial support from the EC (FORECAST 668983 and MEPHOS 872648). A.R.A. acknowledges the “Programa Operacional Regional do Norte”, “Fundo Social Europeu”, and Norte2020 TERM&SC, for her PhD grant (NORTE-08-5369-FSE-000044). |
| وصف الملف: | application/pdf |
| تدمد: | 2373-9878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d618110b5cc230a4b6a279d409925ba https://doi.org/10.1021/acsbiomaterials.0c01698 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d618110b5cc230a4b6a279d409925ba |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 23739878 |
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