A case of stage IV gastric cancer with para-aortic lymph node metastasis showing pathological complete response after neoadjuvant chemotherapy
| العنوان: | A case of stage IV gastric cancer with para-aortic lymph node metastasis showing pathological complete response after neoadjuvant chemotherapy |
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| المؤلفون: | Takehiro Okabayashi, Kazuhide Ozaki, Manabu Matsumoto, Yuichi Shibuya, Yuki Katsura |
| المصدر: | Surgical Case Reports, Vol 6, Iss 1, Pp 1-5 (2020) Surgical Case Reports |
| بيانات النشر: | SpringerOpen, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, lcsh:Surgery, Case Report, 030230 surgery, Gastroenterology, Metastasis, Conversion surgery, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Lymph node, Chemotherapy, Pathological complete response, business.industry, Cancer, lcsh:RD1-811, medicine.disease, Primary tumor, Oxaliplatin, Regimen, medicine.anatomical_structure, Para-aortic lymph node metastasis, 030220 oncology & carcinogenesis, Gastrectomy, business, Gastric cancer, medicine.drug |
| الوصف: | Background Stage IV advanced gastric cancer with para-aortic lymph node metastasis (PALM) is considered unresectable. Systemic chemotherapy is the treatment of choice for such tumors, while conversion surgery may be a treatment option in the case chemotherapy is effective but R0 resection is possible. We report a case of stage IV gastric cancer with PALM that showed pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) using S-1, oxaliplatin, and trastuzumab (SOX+HER). Case presentation A 69-year-old woman who was diagnosed with type 4 stage IV gastric cancer with PALM underwent five courses of NAC with the SOX+HER regimen. The primary tumor and the PALM shrank after treatment, suggesting that the NAC induced a partial response. We performed a total gastrectomy plus distal pancreaticosplenectomy with para-aortic lymph node dissection. Histological analysis revealed no remnant cancer cells in the primary tumor or the lymph nodes, confirming a pCR. The postoperative course was uneventful, and the patient was discharged on day 14 after the operation. S-1 was started as adjuvant chemotherapy, and the patient remains alive without recurrence 2 months after surgery. Conclusion This case shows the possibility of conversion surgery after SOX+HER therapy for stage IV advanced gastric cancer with PALM. |
| اللغة: | English |
| تدمد: | 2198-7793 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d68d08ed4de496a866f88f018fd1c0a https://doaj.org/article/1d70014f003b44829caa61b75c42e692 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7d68d08ed4de496a866f88f018fd1c0a |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 21987793 |
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