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Rethinking the composition of a rational antibiotic arsenal for the 21st century

التفاصيل البيبلوغرافية
العنوان: Rethinking the composition of a rational antibiotic arsenal for the 21st century
المؤلفون: Margaret A. Riley, Christopher M. Roy, Robert L. Dorit, Sandra M. Robinson
المصدر: Future Medicinal Chemistry. 5:1231-1242
بيانات النشر: Future Science Ltd, 2013.
سنة النشر: 2013
مصطلحات موضوعية: medicine.drug_class, Antibiotics, Colicins, Biology, Niacin, Cripple, Bacteriocins, Drug Resistance, Bacterial, Drug Discovery, medicine, Animals, Humans, Bacteriophages, Microbiome, Composition (language), Pharmacology, business.industry, Imidazoles, Human microbiome, Environmental ethics, Bacterial Infections, Anti-Bacterial Agents, Germ theory of disease, Biotechnology, Urinary Tract Infections, Molecular Medicine, Drug Therapy, Combination, business
الوصف: The importance of the human microbiome in health may be the single most valuable development in our conception of the microbial world since Pasteur’s germ theory of the 1860s. Its implications for our understanding of health and pathogenesis are profound. Coupled with the revolution in diagnostics that we are now witnessing – a revolution that changes medicine from a science of symptoms to a science of causes – we cannot continue to develop antibiotics as we have for the past 80 years. Instead, we need to usher in a new conception of the role of antibiotics in treatment: away from single molecules that target broad phylogenetic spectra and towards targeted molecules that cripple the pathogen while leaving the rest of the microbiome largely intact.
تدمد: 1756-8927
1756-8919
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd6b339bd5c3952110e3aa4dc3c8895
https://doi.org/10.4155/fmc.13.79
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....7dd6b339bd5c3952110e3aa4dc3c8895
قاعدة البيانات: OpenAIRE
الوصف
تدمد:17568927
17568919