Tamoxifen improves homeostasis in the peri‐implant bone remodeling of osseointegrated titanium implants
| العنوان: | Tamoxifen improves homeostasis in the peri‐implant bone remodeling of osseointegrated titanium implants |
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| المؤلفون: | Luiz Guilherme Fiorin, Henrique Rinaldi Matheus, Edilson Ervolino, Elena Canciani, Gaia Pellegrini, Claudia Dellavia, Carlo Maiorana, Juliano Milanezi de Almeida |
| المصدر: | Journal of Periodontal Research. 57:880-890 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Dental Implants, Titanium, Tibia, Settore BIO/16 - Anatomia Umana, Osteocalcin, bone remodeling, dental implants, selective estrogen receptor modulators, tamoxifen, Rats, Tamoxifen, Settore MED/28 - Malattie Odontostomatologiche, Osseointegration, Animals, Homeostasis, Periodontics, Female |
| الوصف: | The purpose of this preclinical study was to evaluate the influence of tamoxifen (TAM) on the peri-implant bone remodeling of osseointegrated titanium implants in ovariectomized female rats.Seventy-two female rats underwent bilateral ovariectomy 20 weeks before implants placement. One titanium implant was inserted in each tibia of the animals. Six weeks following the implant surgery, animals were randomly divided into two experimental groups (n = 36), which received either saline solution (SS) or tamoxifen citrate (TAM) via gavage until euthanasia. Euthanasia was performed at 30, 60, and 90 days after the first gavage. Assessments of bone to implant contact (BIC), bone ingrowth percentage (BIN), morphological description of cellular and tissue reactions, immunohistochemistry for the detection of bone morphogenetic protein 2/4 (BMP2/4), runt-related transcription factor 2 (RUNX-2), osteocalcin (OCN) and tartrate-resistant acid phosphatase (TRAP), and bone chemical composition through scanning electron microscopy with energy-dispersive x-ray spectroscopy were performed.Tamoxifen group presented higher BIC, higher BIN, higher RUNX-2 and OCN, lower TRAP-positive cells/mmTamoxifen enhanced the remodeling of the bone surrounding titanium implants in ovariectomized rats. |
| تدمد: | 1600-0765 0022-3484 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de6619038f54b85865c8dcd77540c01 https://doi.org/10.1111/jre.13026 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7de6619038f54b85865c8dcd77540c01 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000765 00223484 |
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