LACK OF CORRELATION BETWEEN SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND PHOTOISOMERIZATION OF EPIDERMAL UROCANIC ACID IN THE HAIRLESS MOUSE
| العنوان: | LACK OF CORRELATION BETWEEN SUPPRESSION OF CONTACT HYPERSENSITIVITY BY UV RADIATION AND PHOTOISOMERIZATION OF EPIDERMAL UROCANIC ACID IN THE HAIRLESS MOUSE |
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| المؤلفون: | Meira Bosnic, Vivienne E. Reeve, Ronald D. Ley, Christa Boehm-Wilcox, R B Cope |
| المصدر: | Photochemistry and Photobiology. 60:268-273 |
| بيانات النشر: | Wiley, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Male, Erythema, Ultraviolet Rays, Dermatitis, Contact, Photochemistry, Biochemistry, Mice, chemistry.chemical_compound, Edema, medicine, Animals, Irradiation, Physical and Theoretical Chemistry, Skin, Mice, Hairless, integumentary system, Epidermis (botany), Urocanic Acid, Dose-Response Relationship, Radiation, General Medicine, medicine.disease, Fluorescence, Molecular biology, Hairless, Urocanic acid, chemistry, Female, sense organs, medicine.symptom, Contact dermatitis |
| الوصف: | The immunological consequences of exposure to UVA (320-400 nm) radiation are unclear. This study describes the relationship between the generation of epidermal cis-urocanic acid and the ability to respond to a contact-sensitizing agent, in hairless mice exposed to different UV radiation sources, which incorporate successively greater short-wavelength cutoff by filtration of the radiation from fluorescent UV tubes. Mice were exposed to these radiation sources at doses systematically varying in UVB radiation content but supplying increasing proportions of UVA radiation. All radiation sources were found to generate approximately 35% cis-urocanic acid in the epidermis, thus normalizing the sources for cis-urocanic acid production. However, only those sources richest in short-wavelength UVB resulted in suppression of the systemic contact hypersensitivity response. These sources also induced the greatest erythema reaction, measured as its edema component, in the exposed skin. A strong correlation was thus demonstrated between the induction of edema and the suppression of contact hypersensitivity, but there appeared to be no correlation between the generation of epidermal cis-urocanic acid and suppression of contact hypersensitivity. The sources richest in UVA content did not result in suppression of contact hypersensitivity; furthermore mice previously irradiated with such UVA-rich sources were refractory to the immunosuppressive action of exogenous cis-urocanic acid. A protective effect of the increased UVA content thus appeared to be inhibiting immunosuppression by the available endogenously generated or exogenously applied cis-urocanic acid. |
| تدمد: | 1751-1097 0031-8655 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e16340ea764042552a857aba6674ebd https://doi.org/10.1111/j.1751-1097.1994.tb05103.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7e16340ea764042552a857aba6674ebd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17511097 00318655 |
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