Lymph node reticulum cell neoplasm with progression into cytokeratin-positive interstitial reticulum cell (CIRC) sarcoma: a case study
| العنوان: | Lymph node reticulum cell neoplasm with progression into cytokeratin-positive interstitial reticulum cell (CIRC) sarcoma: a case study |
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| المؤلفون: | Carla Franco, Marco Lucioni, Marco Benazzo, Alessandra Viglio, Emanuela Boveri, M. Lazzarino, R. Rosso, P Incardona, Roberta Riboni, Vittorio Necchi, A. Canevari, Marco Paulli, M Danova, Umberto Magrini |
| المصدر: | Histopathology. 43:583-591 |
| بيانات النشر: | Wiley, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Histology, Vimentin, Pathology and Forensic Medicine, Cytokeratin, Reticular cell, medicine, Humans, Lymph node, Aged, Fascin, biology, Sarcoma, Anatomical pathology, General Medicine, medicine.disease, Immunohistochemistry, Microscopy, Electron, medicine.anatomical_structure, Disease Progression, biology.protein, Keratins, Female, Lymph Nodes, Lymph |
| الوصف: | Aims: To detail on sequential biopsies the morphological and immunohistochemical features of a case of primary lymph nodal fibroblastic reticulum cell (FBRC) tumour which progressed into a clinically aggressive cytokeratin-positive interstitial reticulum cell (CIRC) sarcoma. Methods and results: A 70-year-old female underwent surgical excision of an enlarged submandibular lymph node. The nodal architecture was effaced by a neoplastic proliferation of medium to large cells, round to oval to spindle in shape, growing in a storiform pattern. The tumour stained for vimentin, CD68, factor XIIIa, α1-antitrypsin, fascin and actin. Dendritic and endothelial cell markers were negative. A diagnosis of FBRC tumour was made by combining pathological and clinical data. The patient received no therapy but 5 months later the tumour relapsed, exhibiting a deceptively pleomorphic cytology, phenotypic changes (strong cytokeratin positivity), intense p53 expression and aggressive clinical course with fatal outcome. In-situ hybridization for Epstein–Barr virus was negative. Conclusions: We speculate that the morphological changes and p53 expression of the relapsing neoplasm might reflect tumour cell dedifferentiation, in keeping with the aggressive clinical course. The intense p53 expression suggests that this oncoprotein might also play a role in reticulum cell tumorigenesis. |
| تدمد: | 1365-2559 0309-0167 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1a87dc9e3a036bfbfb7540bc8eaafb https://doi.org/10.1111/j.1365-2559.2003.01725.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....7e1a87dc9e3a036bfbfb7540bc8eaafb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652559 03090167 |
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