The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells
| العنوان: | The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells |
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| المؤلفون: | Sandrine Henri, Hervé Luche, Laurence Ardouin, Bernard Malissen, Miriam Merad, Peter See, Pearline Teo, Florent Ginhoux |
| المساهمون: | Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Mount Sinai School of Medicine, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Department of Gene and Cell Medicine [New York], Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | European Journal of Immunology European Journal of Immunology, Wiley-VCH Verlag, 2011, 41 (8), pp.2165-75. ⟨10.1002/eji.201141728⟩ European Journal of Immunology, 2011, 41 (8), pp.2165-75. ⟨10.1002/eji.201141728⟩ |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Myeloid, Time Factors, MESH: Spleen, Cellular differentiation, T-Lymphocytes, MESH: Interleukin-2 Receptor alpha Subunit, MESH: Flow Cytometry, Mice, 0302 clinical medicine, Immunology and Allergy, MESH: Animals, Myeloid Cells, IL-2 receptor, 0303 health sciences, biology, MESH: Dendritic Cells, Cell Differentiation, Flow Cytometry, 3. Good health, Cell biology, medicine.anatomical_structure, Hyaluronan Receptors, Antigens, Surface, Interferon Regulatory Factors, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, MESH: Interferon Regulatory Factors, MESH: Cell Differentiation, Langerin, MESH: Mice, Transgenic, MESH: Antigens, Surface, CD8 Antigens, Immunology, Green Fluorescent Proteins, Double negative, CD11c, chemical and pharmacologic phenomena, Mice, Transgenic, Thymus Gland, MESH: Antigens, CD44, MESH: Models, Immunological, Article, 03 medical and health sciences, MESH: Green Fluorescent Proteins, MESH: Mice, Inbred C57BL, MESH: Mannose-Binding Lectins, medicine, CD135, Animals, Lectins, C-Type, Progenitor cell, MESH: Mice, 030304 developmental biology, MESH: Time Factors, Interleukin-2 Receptor alpha Subunit, Models, Immunological, MESH: Thymus Gland, Dendritic Cells, MESH: Myeloid Cells, MESH: Male, Mice, Inbred C57BL, MESH: T-Lymphocytes, Mannose-Binding Lectins, biology.protein, MESH: Antigens, CD8, MESH: Female, MESH: Lectins, C-Type, Spleen, 030215 immunology |
| الوصف: | International audience; The dendritic cells (DCs) present in lymphoid and non-lymphoid organs are generated from progenitors with myeloid-restricted potential. However, in the thymus a major subset of DCs expressing CD8α and langerin (CD207) appears to stand apart from all other DCs in that it is thought to derive from progenitors with lymphoid potential. Using mice expressing a fluorescent reporter and a diphtheria toxin receptor under the control of the cd207 gene, we demonstrated that CD207(+) CD8α(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors that express markers that are normally present on all (CD11c(+) and MHCII molecules) or on some (CD207, CD135, CD8α, CX3CR1) DC subsets. Those intrathymic myeloid-type precursors correspond to CD44(+) CD25(-) double-negative 1c (DN1c) cells and are continuously renewed from bone marrow-derived canonical DC precursors. In conclusion, our results demonstrate that the earliest intrathymic precursors of CD8α(+) thymic DCs correspond to myeloid-type DN1c cells and support the view that under physiological conditions myeloid-restricted progenitors generate the whole constellation of DCs present in the body including the thymus. |
| تدمد: | 1521-4141 0014-2980 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e383ee1addea003cde91538a46b1278 https://pubmed.ncbi.nlm.nih.gov/21792873 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7e383ee1addea003cde91538a46b1278 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15214141 00142980 |
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