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Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis

التفاصيل البيبلوغرافية
العنوان: Asperunguisins A-F, Cytotoxic Asperane Sesterterpenoids from the Endolichenic Fungus Aspergillus unguis
المؤلفون: Yue-Lan Li, Chun-Yu Liu, Yun Gao, Hong-Xiang Lou, Chun-Jing Sun, Zun-Tian Zhao
المصدر: Journal of natural products. 82(6)
سنة النشر: 2019
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Sesterterpenes, Pharmaceutical Science, Antineoplastic Agents, Fungus, Crystallography, X-Ray, 01 natural sciences, Analytical Chemistry, Microbiology, Drug Discovery, Cytotoxic T cell, Humans, Pharmacology, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Aspergillus unguis, Fungi, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Aspergillus, Complementary and alternative medicine, Aspergilloxide, A549 Cells, Molecular Medicine
الوصف: Six new asperane-type sesterterpenoids, asperunguisins A-F (1-6), were isolated from the endolichenic fungus Aspergillus unguis, together with a known analogue, aspergilloxide (7); these are rare asperane-type sesterterpenoids, characterized by a unique hydroxylated 7/6/6/5 tetracyclic system. The structures of asperunguisins A-F (1-6) were elucidated on the basis of spectroscopic methods (NMR and HRESIMS), X-ray single-crystal diffraction analysis, ECD calculations, and biogenetic considerations. Asperunguisin C (3) showed cytotoxicity against the human cancer cell line A549 with an IC
تدمد: 1520-6025
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3ef5a3d25af2a5ffd5e8f06a291a5a
https://pubmed.ncbi.nlm.nih.gov/31117521
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....7e3ef5a3d25af2a5ffd5e8f06a291a5a
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15206025