Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL
| العنوان: | Hydrogen sulfide destroys lipid hydroperoxides in oxidized LDL |
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| المؤلفون: | Stylianos Kapiotis, Sabine M. Schreier, Markus K. Muellner, Marcela Hermann, Bernhard Gmeiner, Harald Esterbauer, Markus Exner, Hilde Laggner |
| المصدر: | Biochemical Journal. 420:277-281 |
| بيانات النشر: | Portland Press Ltd., 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Lipid Peroxides, Time Factors, Hydrogen sulfide, Endogeny, Thiobarbituric Acid Reactive Substances, Biochemistry, High-performance liquid chromatography, Gene Expression Regulation, Enzymologic, chemistry.chemical_compound, Malondialdehyde, Humans, Linoleic Acids, Conjugated, Hydrogen Sulfide, Antiatherogenic agent, Molecular Biology, Cells, Cultured, Chromatography, High Pressure Liquid, Analysis of Variance, Dose-Response Relationship, Drug, Reverse Transcriptase Polymerase Chain Reaction, Endothelial Cells, Cell Biology, equipment and supplies, Haem Oxygenase, Lipoproteins, LDL, Linoleic Acids, chemistry, Low-density lipoprotein, lipids (amino acids, peptides, and proteins), Heme Oxygenase-1, Oxidized ldl, Lipoprotein |
| الوصف: | LOOHs (lipid hydroperoxides) in oxLDL [oxidized LDL (low-density lipoprotein)] are potentially atherogenic compounds. Recently, H2S was identified as the third endogenous gasotransmitter in the vasculature. H2O2 is known to be destroyed by H2S. Assuming that H2S may also react with LOOHs, the results show that H2S can destroy LOOHs in oxLDL. The ability of LOOH-enriched LDL to induce HO-1 (haem oxygenase 1) in endothelial cells was abolished by H2S pretreatment. HPLC analysis showed that 9-HPODE [(9S)-hydroperoxy-(10E,12Z)-octadecadienoic acid], a compound found in oxLDL, was reduced to 9-HODE [(9S)-hydroxy-(10E,12Z)-octadecadienoic acid] in the presence of H2S. Thus H2S may act as an antiatherogenic agent by reducing LOOHs to the less reactive LOHs and could abrogate the pathobiological activity of oxLDL. |
| تدمد: | 1470-8728 0264-6021 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e937f0bd7e3ca0af579c296a824bcec https://doi.org/10.1042/bj20082421 |
| رقم الأكسشن: | edsair.doi.dedup.....7e937f0bd7e3ca0af579c296a824bcec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14708728 02646021 |
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