Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke
| العنوان: | Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke |
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| المؤلفون: | Sabri Ogullar, Erkan Cure, Medine Cumhur Cure, Huseyin Unal, Aynur Kirbas, Suleyman Yuce, Serkan Kirbas, Ahmet Tufekci, Sevim Cakmak |
| المساهمون: | RTEÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü |
| المصدر: | Annals of Indian Academy of Neurology Annals of Indian Academy of Neurology, Vol 16, Iss 4, Pp 498-503 (2013) |
| بيانات النشر: | Medknow Publications & Media Pvt Ltd, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Tumor Necrosis Factor-Alpha, medicine.medical_specialty, Small Dense-Low-Density Lipoprotein, Lipid Subfraction, Alpha (ethology), lcsh:RC346-429, Nitric oxide, chemistry.chemical_compound, lipid subfraction, Internal medicine, small dense-low-density lipoprotein, ischemic stroke, Medicine, cardiovascular diseases, Risk factor, Stroke, lcsh:Neurology. Diseases of the nervous system, tumor necrosis factor-alpha, Ischemic Stroke, business.industry, medicine.disease, Carotid Artery Intima-Media Thickness, Intima-media thickness, chemistry, Ischemic stroke, Cardiology, Carotid artery intima-media thickness, Tumor necrosis factor alpha, Original Article, Neurology (clinical), business, Lipoprotein |
| الوصف: | cure, erkan/0000-0001-7807-135X; Cure, Medine Cumhur/0000-0001-9253-6459 WOS: 000326976700007 PubMed: 24339567 Objectives: Small dense (sd) low-density lipoprotein (LDL), tumor necrosis factor (TNF) alpha (alpha), and nitric oxide (NO) have recently emerged as important stroke risk factors. the aim of the study was to investigate the effects of increased levels of small LDL particle size, TNF-alpha and NO on the developed ischemic stroke and increased carotid artery intima-media thickness (CIMT). Materials and Methods: A total of 29 women and 25 men (a total of 54 ischemic stroke patients) and a similar age group of 50 controls (29 females and 21 males) were included in the study. CIMT, C-reactive protein (CRP), TNF-alpha, NO, and lipid subfraction test of the two groups were measured. Results: the mean LDL particle size was smaller in patients with stroke than in the controls (26.8 +/- 0.31 nm vs. 27.0 +/- 0.31 nm, P = 0.003). sd-LDL, TNF-alpha, NO, CRP, right CIMT, and left CIMT were higher in patients with stroke than in the controls (respectively; 8.2 +/- 7.8 mg/dL vs. 3.3 +/- 3.5 mg/dL, P < 0.001; 75.6 +/- 25.0 pg/mL vs. 65.4 +/- 9.1 pg/mL, P = 0.009; 76.4 +/- 53.3 mu mol/L vs. 41.5 +/- 27.0 mu mol/L, P < 0.001; 1.9 +/- 2.6 mm vs. 0.4 +/- 0.3 mm P < 0.001; 0.97 +/- 0.38 mm vs. 0.83 +/- 0.15 mm, P = 0.007; 1.04 +/- 0.44 mm vs. 0.87 +/- 0.19 mm, P = 0.010). Conclusion: These results show that sd-LDL is independently associated with the incidence of stroke and may be a risk factor in the development of stroke. in addition, TNF-alpha, NO, right CIMT, and left CIMT may be a risk factor in the development of ischemic stroke. RTEU Bilimsel Arastirmalar Projeleri birimi (BAP)Recep Tayyip Erdogan University [2012.106.01] Source of Support: RTEU Bilimsel Arastirmalar Projeleri birimi (BAP), Project number: 2012.106.01, Conflict of Interest: Nil |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1998-3549 0972-2327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efd4eeb489270f20270f069ea20034c http://europepmc.org/articles/PMC3841588 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7efd4eeb489270f20270f069ea20034c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983549 09722327 |
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