Impact of groin flap ischemia-reperfusion on red blood cell micro-rheological parameters in a follow-up study on rats
| العنوان: | Impact of groin flap ischemia-reperfusion on red blood cell micro-rheological parameters in a follow-up study on rats |
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| المؤلفون: | Zsuzsanna Magyar, Abel Molnar, Anita Mester, David Belkin Nachmias, Viktoria Sogor, Norbert Nemeth, Katalin Peto, Din Mann |
| المصدر: | Clinical Hemorheology and Microcirculation. 79:245-255 |
| بيانات النشر: | IOS Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Erythrocytes, Physiology, Ischemia, 030230 surgery, Groin, Microcirculation, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), medicine, Animals, Elméleti orvostudományok, business.industry, Orvostudományok, Hematology, medicine.disease, Rats, Surgery, Disease Models, Animal, Red blood cell, medicine.anatomical_structure, Reperfusion Injury, 030220 oncology & carcinogenesis, Reperfusion, Hemorheology, Cardiology and Cardiovascular Medicine, business, Wound healing, Perfusion, Groin flap, Follow-Up Studies |
| الوصف: | BACKGROUND: Flap hypoperfusion or ischemia-reperfusion (I/R) may occur during preparation-transposition procedures and by postoperative thrombotic complications. Behind the microcirculatory disturbances micro-rheological alterations are also supposed. OBJECTIVE: We aimed to investigate the groin flap I/R with following-up micro-rheological parameters. METHODS: Anesthetized rats were subjected to Control or I/R groups. Groin flaps were prepared bilaterally, pedicled on the superficial epigastric vessels. In the Control group the flaps were re-sutured after one hour, while in I/R group microvascular clips were applied on the pedicles for 60 minutes, then the flaps were repositioned. Besides daily wound control, before the operation and on the 1st, 3rd, 5th, 7th and 14th postoperative days blood samples were collected for testing red blood cell (RBC) deformability (rotational ektacytometry) and aggregation (light-transmission aggregometry). RESULTS: RBC deformability significantly worsened by the 3rd–7th postoperative day in I/R group. RBC aggregation enhanced significantly by the 1st day, in I/R group it remained elevated on the 3rd day as well. In a complicated case with unilateral flap necrosis, RBC deformability and aggregation worsening was outlined from its group (base, 1st, 3rd day). CONCLUSION: Wound healing affected micro-rheological parameters in the early postoperative period. Flap I/R exacerbated the alterations. The parameters markedly worsened in case of flap necrosis. |
| وصف الملف: | application/pdf |
| تدمد: | 1875-8622 1386-0291 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f16b9f5d0e77be1598ce4ff3af09bda https://doi.org/10.3233/ch-170277 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7f16b9f5d0e77be1598ce4ff3af09bda |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758622 13860291 |
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