التفاصيل البيبلوغرافية
العنوان:
Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
المؤلفون:
Tran Chinh Viet , Charles R. Kissinger , Daniel A. Norris , Ruhi Kamran , Amit M. Shah , Jingjing Zhao , Yuefen Zhou , Rupal Patel , Matthew Lardy , Darian M. Bartkowski , Richard E. Showalter , Stephen E. Webber , Laurie A. LeBrun , Mei Tsan , Douglas E. Murphy , Sun Hee Kim , Maria V. Sergeeva , Leo Kirkovsky , Martin T. Tran , Thomas G. Nolan , Qing Han , Frank Ruebsam , Lian-Sheng Li , Peter S. Dragovich
المصدر:
Bioorganic & Medicinal Chemistry Letters . 18:3616-3621
بيانات النشر:
Elsevier BV, 2008.
سنة النشر:
2008
مصطلحات موضوعية:
Models, Molecular , Hepatitis C virus , Clinical Biochemistry , Pharmaceutical Science , Microbial Sensitivity Tests , Viral Nonstructural Proteins , Crystallography, X-Ray , medicine.disease_cause , Antiviral Agents , Biochemistry , Cell Line , Structure-Activity Relationship , Drug Discovery , medicine , Animals , Humans , Transferase , Structure–activity relationship , Pyrroles , Replicon , Molecular Biology , chemistry.chemical_classification , Binding Sites , Molecular Structure , biology , Chemistry , Organic Chemistry , Hydrogen Bonding , Nucleotidyltransferase , In vitro , Pyridazines , Enzyme , Enzyme inhibitor , biology.protein , Molecular Medicine
الوصف:
Pyrrolo[1,2-b]pyridazin-2-one analogs were discovered as a novel class of inhibitors of genotype 1 HCV NS5B polymerase. Structure-based design led to the discovery of compound 3 k, which displayed potent inhibitory activities in biochemical and replicon assays (IC(50) (1b)10nM; EC(50) (1b)=12 nM) as well as good stability towards human liver microsomes (HLM t(1/2)60 min).
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ad75b76b7814c0968de6c9e82a0a6 https://doi.org/10.1016/j.bmcl.2008.04.066
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....7f4ad75b76b7814c0968de6c9e82a0a6
قاعدة البيانات:
OpenAIRE
